| Description : |
This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
95.9 kDa |
| AA Sequence : |
MGNRGMEDLIPLVNRLQDAFSAIGQ NADLDLPQIAVVGGQSAGKSSVLEN FVGRDFLPRGSGIVTRRPLVLQLVN ATTEYAEFLHCKGKKFTDFEEVRLE IEAETDRVTGTNKGISPVPINLRVY SPHVLNLTLVDLPGMTKVPVGDQPP DIEFQIRDMLMQFVTKENCLILAVS PANSDLANSDALEVAKEVDPQGQRT IGVITKLDLMDEGTDARDVLENKLL PLRRGYIGVVNRSQKDIDGKKDITA ALAAERKFFLSHPSYRHLADRMGTP YLQKVLNQQLTDHIRDTLPGLRNKL QSQLLSIEKEVEEYKNFRPDDPARK TKALLQMVQQFAVDFEKRIEGSGDQ IDTYELSGGARINRIFHERFPFELV KMEFDEKELRREISYAIKNIHGIRT GLFTPDMAFETIVKKQVKKIREPCL KCVDMVISELISTVRQCTKKLQQYP RLREEMERIVTTHIREREGRTKEQV MLLIDIELAYMNTNHEDFIGFANAQ QRSNQMNKKKTSGNQDEILVIRKGW LTINNIGIMKGGSKEYWFVLTAENL SWYKDDEEKEKKYMLSVDNLKLRDV EKGFMSSKHIFALFNTEQRNVYKDY RQLELACETQEEVDSWKASFLRAGV YPERVGDKEKASETEENGSDSFMHS MDPQLERQVETIRNLVDSYMAIVNK TVRDLMPKTIMHLMINNTKEFIFSE LLANLYSCGDQNTLMEESAEQAQRR DEMLRMYHALKEALSIIGDINTTTV STPMPPPVDDSWLQVQSVPAGRRSP TSSPTPQRRAPAVPPARPGSRGPAP GPPPAGSAMGGAPPVPSRPGASPDP FGPPPQVPSRPNRAPPGVPRITISD PTRTRPLEQKLISEEDLAANDILDY KDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
