Recombinant Human EGFR, Fc Chimera
Cat.No. : | EGFR-692H |
Product Overview : | Recombinant human EGFR (NP_005219) extracellular domain (Met1-Gly640), fused with the Fc region of human IgG1 at the C-terminus, was produced in HEK293. |
Availability | February 16, 2025 |
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Source : | Human Cells(HEK293) |
Species : | Human |
Tag : | Fc |
Predicted N Terminal : | Leu 25 |
Form : | Lyophilized from sterile PBS, pH7.4. |
Molecular Mass : | The recombinant human EGFR/Fc chimera is a homodimeric protein. The reduced monomer consists of 860 amino acids and has a calculated molecular mass of 95 KDa. As a result of glycosylation, the recombinant protein migrates as an approximately 130-140 KDa p |
Endotoxin : | < 1.0 eu per μg of the protein as determined by the LAL method. |
Purity : | >97% as determined by SDS-PAGE. |
Stability : | Samples are stable for up to twelve months from date of receipt at -70oC. |
Storage : | Store it under sterile conditions at -20oC~-70oC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Protein length : | Met1-Gly640 |
Publication : |
Nanofitin as a new molecular imaging agent for diagnosis of EGFR overexpressing tumors. (2017)
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Gene Name : | EGFR epidermal growth factor receptor [ Homo sapiens ] |
Official Symbol : | EGFR |
Gene ID : | 1956 |
mRNA Refseq : | NM_005228 |
Protein Refseq : | NP_005219 |
MIM : | 131550 |
UniProt ID : | P00533 |
Chromosome Location : | 7p12 |
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Customer Reviews (3)
Write a reviewThe powerful biological activity of EGFR combined with its high purity makes the experimental results highly reproducible, which is of great significance in the field of scientific research.
Due to the short half-life and high clearance characteristics of EGFR, they can better adapt to the needs of clinical treatment and provide more treatment options for patients.
The production process of EGFR uses advanced biotechnology, which makes the production process more efficient and environmentally friendly, and reduces the consumption of human and material resources.
Q&As (6)
Ask a questionIt is associated with biological processes in human embryonic development and tissue regeneration.
EGFR inhibits adverse drug reactions such as rash, inflammation, and diarrhea during drug treatment.
The role of EGFR in tumor treatment is to act as a molecular marker and can be used as a prognostic indicator and monitor tumor progression; at the same time, EGFR mutations can also be targeted for targeted therapy.
EGFR gene mutation detection generally uses PCR, fluorescence in situ hybridization, and direct sequencing.
The combination of EGFR inhibitors with chemotherapy drugs, radiotherapy, immunotherapy, etc. can increase the efficacy of treatment and reduce the occurrence of adverse reactions.
EGFR mutations can have a significant impact on the efficacy of targeted therapies, and patients with mutations have higher response rates.
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