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Recombinant Human EGFR, Fc Chimera

Cat.No. : EGFR-692H
Product Overview : Recombinant human EGFR (NP_005219) extracellular domain (Met1-Gly640), fused with the Fc region of human IgG1 at the C-terminus, was produced in HEK293.
Availability February 16, 2025
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Source : Human Cells(HEK293)
Species : Human
Tag : Fc
Predicted N Terminal : Leu 25
Form : Lyophilized from sterile PBS, pH7.4.
Molecular Mass : The recombinant human EGFR/Fc chimera is a homodimeric protein. The reduced monomer consists of 860 amino acids and has a calculated molecular mass of 95 KDa. As a result of glycosylation, the recombinant protein migrates as an approximately 130-140 KDa p
Endotoxin : < 1.0 eu per μg of the protein as determined by the LAL method.
Purity : >97% as determined by SDS-PAGE.
Stability : Samples are stable for up to twelve months from date of receipt at -70oC.
Storage : Store it under sterile conditions at -20oC~-70oC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Protein length : Met1-Gly640
Publication :
Nanofitin as a new molecular imaging agent for diagnosis of EGFR overexpressing tumors. (2017)
Gene Name : EGFR epidermal growth factor receptor [ Homo sapiens ]
Official Symbol : EGFR
Gene ID : 1956
mRNA Refseq : NM_005228
Protein Refseq : NP_005219
MIM : 131550
UniProt ID : P00533
Chromosome Location : 7p12

Not For Human Consumption!

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Customer Reviews (3)

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Reviews
09/05/2022

    The powerful biological activity of EGFR combined with its high purity makes the experimental results highly reproducible, which is of great significance in the field of scientific research.

    09/26/2019

      Due to the short half-life and high clearance characteristics of EGFR, they can better adapt to the needs of clinical treatment and provide more treatment options for patients.

      03/23/2019

        The production process of EGFR uses advanced biotechnology, which makes the production process more efficient and environmentally friendly, and reduces the consumption of human and material resources.

        Q&As (6)

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        What biological processes of human embryonic development and tissue regeneration is EGFR associated with? 10/07/2019

        It is associated with biological processes in human embryonic development and tissue regeneration.

        Why does EGFR-inhibiting drug therapy have adverse reactions? 09/25/2019

        EGFR inhibits adverse drug reactions such as rash, inflammation, and diarrhea during drug treatment.

        What is the role of EGFR in tumor treatment? 08/27/2019

        The role of EGFR in tumor treatment is to act as a molecular marker and can be used as a prognostic indicator and monitor tumor progression; at the same time, EGFR mutations can also be targeted for targeted therapy.

        What are the general methods used for EGFR gene mutation testing? 03/22/2019

        EGFR gene mutation detection generally uses PCR, fluorescence in situ hybridization, and direct sequencing.

        What other drugs can EGFR inhibitors be combined with to increase efficacy? 02/21/2019

        The combination of EGFR inhibitors with chemotherapy drugs, radiotherapy, immunotherapy, etc. can increase the efficacy of treatment and reduce the occurrence of adverse reactions.

        How do EGFR mutations affect the efficacy of targeted therapies? 02/04/2019

        EGFR mutations can have a significant impact on the efficacy of targeted therapies, and patients with mutations have higher response rates.

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