Recombinant Human FGF23, His-tagged
| Cat.No. : | FGF23-28141TH |
| Product Overview : | Recombinant full length Human FGF 23 fused at the C-terminus to a His tag, 35kDa. |
- Specification
- Gene Information
- Related Products
| Description : | The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The product of this gene inhibits renal tubular phosphate transport. This gene was identified by its mutations associated with autosomal dominant hypophosphatemic rickets (ADHR), an inherited phosphate wasting disorder. Abnormally high level expression of this gene was found in oncogenic hypophosphatemic osteomalacia (OHO), a phenotypically similar disease caused by abnormal phosphate metabolism. Mutations in this gene have also been shown to cause familial tumoral calcinosis with hyperphosphatemia. |
| Protein length : | 251 amino acids |
| Conjugation : | HIS |
| Molecular Weight : | 35.000kDa inclusive of tags |
| Source : | HEK 293 cells |
| Tissue specificity : | Expressed in osteogenic cells particularly during phases of active bone remodeling. In adult trabecular bone, expressed in osteocytes and flattened bone-lining cells (inactive osteoblasts). |
| Biological activity : | Activates ERK and FRS2a phosphorylation in Klotho expressing cells. |
| Form : | Liquid |
| Purity : | >90% by SDS-PAGE |
| Storage buffer : | Preservative: NoneConstituents: PBS |
| Storage : | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Sequence Similarities : | Belongs to the heparin-binding growth factors family. |
| Gene Name : | FGF23 fibroblast growth factor 23 [ Homo sapiens ] |
| Official Symbol : | FGF23 |
| Synonyms : | FGF23; fibroblast growth factor 23; |
| Gene ID : | 8074 |
| mRNA Refseq : | NM_020638 |
| Protein Refseq : | NP_065689 |
| MIM : | 605380 |
| Uniprot ID : | Q9GZV9 |
| Chromosome Location : | 12p13 |
| Pathway : | Downstream signaling of activated FGFR, organism-specific biosystem; FGF signaling pathway, organism-specific biosystem; FGFR ligand binding and activation, organism-specific biosystem; FGFR1 ligand binding and activation, organism-specific biosystem; FGFR1c and Klotho ligand binding and activation, organism-specific biosystem; |
| Function : | growth factor activity; protein tyrosine kinase activity; type 1 fibroblast growth factor receptor binding; |
Products Types
| ◆ Recombinant Protein | ||
| Fgf23-2998M | Recombinant Mouse Fgf23 Protein, Myc/DDK-tagged | +Inquiry |
| FGF23-1014H | Recombinant Human FGF23 Protein (Y25-R179), His tagged | +Inquiry |
| FGF23-908H | Recombinant Human FGF23 Protein, His (Fc)-Avi-tagged | +Inquiry |
| FGF23-1990R | Recombinant Rat FGF23 Protein, His (Fc)-Avi-tagged | +Inquiry |
| FGF23-118F | Active Recombinant Human FGF23 Protein (228 aa) | +Inquiry |
| ◆ Lysates | ||
| FGF23-6241HCL | Recombinant Human FGF23 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (7)
Ask a question
What role does FGF23 play in chronic kidney disease?
06/12/2022
FGF23 levels are elevated in chronic kidney disease, contributing to mineral imbalance.
How is FGF23 implicated in cardiovascular health?
04/04/2022
High FGF23 levels are associated with increased cardiovascular risk.
How does FGF23 regulate phosphate and calcium homeostasis?
03/24/2022
It decreases renal phosphate reabsorption and 1,25-dihydroxyvitamin D production.
Are there known genetic mutations that affect FGF23 production or activity?
01/27/2022
Mutations in FGF23 or related proteins can lead to dysregulated phosphate metabolism.
What therapeutic strategies are being explored to modulate FGF23 levels?
05/16/2020
Strategies include phosphate binders and FGF23 antibodies to manage elevated FGF23 levels.
In which tissues is FGF23 predominantly produced and secreted?
04/28/2020
FGF23 is primarily produced in bone.
What is the primary function of FGF23 in the body?
10/29/2019
FGF23 regulates phosphate and vitamin D metabolism.
Customer Reviews (3)
Write a reviewReviews
07/23/2022
Excellent results, high purity. -
07/17/2021
Reliable and effective product. -
11/26/2020
Quick delivery, product works. -
Ask a Question for All FGF23 Products
Required fields are marked with *
My Review for All FGF23 Products
Required fields are marked with *
0
Inquiry Basket
