Recombinant Human FGF23, His-tagged

Cat.No. : FGF23-28141TH
Product Overview : Recombinant full length Human FGF 23 fused at the C-terminus to a His tag, 35kDa.
  • Specification
  • Gene Information
  • Related Products
Description : The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The product of this gene inhibits renal tubular phosphate transport. This gene was identified by its mutations associated with autosomal dominant hypophosphatemic rickets (ADHR), an inherited phosphate wasting disorder. Abnormally high level expression of this gene was found in oncogenic hypophosphatemic osteomalacia (OHO), a phenotypically similar disease caused by abnormal phosphate metabolism. Mutations in this gene have also been shown to cause familial tumoral calcinosis with hyperphosphatemia.
Protein length : 251 amino acids
Conjugation : HIS
Molecular Weight : 35.000kDa inclusive of tags
Source : HEK 293 cells
Tissue specificity : Expressed in osteogenic cells particularly during phases of active bone remodeling. In adult trabecular bone, expressed in osteocytes and flattened bone-lining cells (inactive osteoblasts).
Biological activity : Activates ERK and FRS2a phosphorylation in Klotho expressing cells.
Form : Liquid
Purity : >90% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: PBS
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Sequence Similarities : Belongs to the heparin-binding growth factors family.
Gene Name : FGF23 fibroblast growth factor 23 [ Homo sapiens ]
Official Symbol : FGF23
Synonyms : FGF23; fibroblast growth factor 23;
Gene ID : 8074
mRNA Refseq : NM_020638
Protein Refseq : NP_065689
MIM : 605380
Uniprot ID : Q9GZV9
Chromosome Location : 12p13
Pathway : Downstream signaling of activated FGFR, organism-specific biosystem; FGF signaling pathway, organism-specific biosystem; FGFR ligand binding and activation, organism-specific biosystem; FGFR1 ligand binding and activation, organism-specific biosystem; FGFR1c and Klotho ligand binding and activation, organism-specific biosystem;
Function : growth factor activity; protein tyrosine kinase activity; type 1 fibroblast growth factor receptor binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (7)

Ask a question
What role does FGF23 play in chronic kidney disease? 06/12/2022

FGF23 levels are elevated in chronic kidney disease, contributing to mineral imbalance.

How is FGF23 implicated in cardiovascular health? 04/04/2022

High FGF23 levels are associated with increased cardiovascular risk.

How does FGF23 regulate phosphate and calcium homeostasis? 03/24/2022

It decreases renal phosphate reabsorption and 1,25-dihydroxyvitamin D production.

Are there known genetic mutations that affect FGF23 production or activity? 01/27/2022

Mutations in FGF23 or related proteins can lead to dysregulated phosphate metabolism.

What therapeutic strategies are being explored to modulate FGF23 levels? 05/16/2020

Strategies include phosphate binders and FGF23 antibodies to manage elevated FGF23 levels.

In which tissues is FGF23 predominantly produced and secreted? 04/28/2020

FGF23 is primarily produced in bone.

What is the primary function of FGF23 in the body? 10/29/2019

FGF23 regulates phosphate and vitamin D metabolism.

Customer Reviews (3)

Write a review
Reviews
07/23/2022

    Excellent results, high purity. -

    07/17/2021

      Reliable and effective product. -

      11/26/2020

        Quick delivery, product works. -

        Ask a Question for All FGF23 Products

        Required fields are marked with *

        My Review for All FGF23 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        Stay Updated on the
        Latest Bioscience Trends

        Copyright © 2023 Creative BioMart. All Rights Reserved.

        Terms and Conditions        Privacy Policy