Recombinant Human FGF23 Protein, His-tagged FGF23-684H

Recombinant Human FGF23 Protein, His-tagged

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Recombinant Human FGF23 Protein, His-tagged

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Cat.No. : FGF23-684H
Product Overview : Recombinant Human FGF23 Protein is produced by Baculovirus expression system. This protein is fused with a His tag.
Description : FGF-23, also known as fibroblast growth factor 23, is a member of the FGF family which is responsible for phosphate and vitamin D metabolism. The main function of this protein seems to be regulation of phosphate concentration in plasma. It is secreted by osteocytes in response to elevated calcitriol and acts on the kidneys, where it decreases the expression of NPT2, a sodium-phosphate cotransporter in the proximal tubule. Thus, FGF-23 interaction with renal proximal tubular epithelium decreases the reabsorption and increases excretion of phosphate. This protein may also suppress 1-alpha-hydroxylase, reducing its ability to activate vitamin D and subsequently impairing calcium absorption. Following secretion this protein is inactivated by cleavage into a N-terminal fragment and a C-terminal fragment. The N-terminal sequence analysis is showing that a C-terminal fragment is detected. Recombinant human FGF-23, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Source : Insect cell
Species : Human
Tag : His
Form : Liquid. In Phosphate Buffered Saline (pH 7.4) containing 2 mM DTT, 1 mM EDTA, 10 % glycerol.
Molecular Mass : 26.4 kDa
Protein length : 25-251 aa
AA Sequence : ADPYPNASPL LGSSWGGLIH LYTATARNSY HLQIHKNGHV DGAPHQTIYS ALMIRSEDAG FVVITGVMSR RYLCMDFRGN IFGSHYFDPE NCRFQHQTLE NGYDVYHSPQ YHFLVSLGRA KRAFLPGMNP PPYSQFLSRR NEIPLIHFNT PIPRRHTRSA EDDSERDPLN VLKPRARMTP APASCSQELP SAEDNSPMAS DPLGVVRGGR VNTHAGGTGP EGCRPFAKFI HHHHHH
Endotoxin : < 1.0 EU per 1 ug of protein (determined by LAL method)
Purity : > 90 % by SDS - PAGE
Notes : For research use only. This product is not intended or approved for human, diagnostics or veterinary use.
Storage : Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 or -70 centigrade. Avoid repeated freezing and thawing cycles.
Concentration : 0.25 mg/ml (determined by Absorbance at 280 nm)
Gene Name : FGF23 fibroblast growth factor 23 [ Homo sapiens ]
Official Symbol : FGF23
Synonyms : Fibroblast growth factor 23; FGF23; ADHR; FGFN; HFTC2; HPDR2; HYPF; PHPTC;
Gene ID : 8074
mRNA Refseq : NM_020638
Protein Refseq : NP_065689
UniProt ID : Q9GZV9

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