Recombinant Human Fibroblast Growth Factor 23
|Product Overview :||Recombinant human FGF23 protein was expressed in E. coli and purified by using conventional chromatography techniques.|
- Gene Information
- Related Products
|Cat. No. :||FGF23-618H|
|Description :||The FGF family plays a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF23, FGF21 and FGF19 constitute an atypical FGF subfamily whose ligands act as circulating hormones and require the participation of a Klotho protein as a co-receptor for their signaling. FGF23 is a bone-derived hormone that acts in the kidney to regulate phosphate homeostasis and vitamin D metabolism. The signaling receptor for FGF23, a Klotho-FGFR1 (IIIc) complex, is an essential regulator of the renal sodium phosphate co-transporter and key vitamin D-metabolizing enzymes CYP27B1 and CYP24A1.|
|Form :||Supplied as a lyophilized powder.|
|Purity :||> 95% by SDS - PAGE|
|Sequence :||Region of FGF23 protein corresponding to amino acids MYPNASPLLG SSWGGLIHLY TATARNSYHL QIHKNGHVDG APHQTIYSAL MIRSEDAGFV VITGVMSRRY LCMDFRGNIF GSHYFDPENC RFQHQTLENG YDVYHSPQYH FLVSLGRAKR AFLPGMNPPP YSQFLSRRNE IPLIHFNTPI PRRHTRSAED DSERDPLNVL KPRARMTPAP ASCS|
|Molecular Mass :||22.5 kDa|
|Applications :||Numerous applications are possible with this product and should be tested by the end user under their own laboratory conditions.|
|Endotoxin Levels :||Endotoxin level is less than 0.1 ng per ug (1 EU/ug).|
|Storage :||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Gene Name :||FGF23 fibroblast growth factor 23 [ Homo sapiens ]|
|Official Symbol :||FGF23|
|Synonyms :||FGF23; fibroblast growth factor 23; ADHR; HYPF; HPDR2; PHPTC; FGF-23; Phosphatonin; UNQ3027/PRO9828; Fibroblast growth factor 23 N-terminal peptide; Fibroblast growth factor 23 C-terminal peptide; tumor-derived hypophosphatemia inducing factor; Tumor-derived hypophosphatemia-inducing factor|
|Gene ID :||8074|
|mRNA Refseq :||NM_020638|
|Protein Refseq :||NP_065689|
|UniProt ID :||Q9GZV9|
|Chromosome Location :||12p13.3|
|Pathway :||MAPK signaling pathway; Melanoma; Pathways in cancer; Regulation of actin cytoskeleton; Signaling by FGFR|
|Function :||growth factor activity|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (7)Ask a question
FGF23 levels are elevated in chronic kidney disease, contributing to mineral imbalance.
High FGF23 levels are associated with increased cardiovascular risk.
It decreases renal phosphate reabsorption and 1,25-dihydroxyvitamin D production.
Mutations in FGF23 or related proteins can lead to dysregulated phosphate metabolism.
Strategies include phosphate binders and FGF23 antibodies to manage elevated FGF23 levels.
FGF23 is primarily produced in bone.
FGF23 regulates phosphate and vitamin D metabolism.
Customer Reviews (3)Write a review
Excellent results, high purity. -
Reliable and effective product. -
Quick delivery, product works. -
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