Recombinant Human FLT3 Protein, MYC/DDK-tagged, C13 and N15-labeled
Cat.No. : | FLT3-088H |
Product Overview : | FLT3 MS Standard C13 and N15-labeled recombinant protein (NP_004110) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
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Description : | This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc&DDK |
Molecular Mass : | 112.7 kDa |
AA Sequence : | MPALARGGGQLPLLVVFSAMIFGTI TNQDLPVIKCVLINHKNNDSSVGKS SSYPMVSESPEDLGCALRPQSSGTV YEAAAVEVDVSASITLQVLVDAPGN ISCLWVFKHSSLNCQPHFDLQNRGV VSMVILKMTETQAGEYLLFIQSEAT NYTILFTVSIRNTLLYTLRRPYFRK MENQDALVCISESVPEPIVEWVLCD SQGESCKEESPAVVKKEEKVLHELF GMDIRCCARNELGRECTRLFTIDLN QTPQTTLPQLFLKVGEPLWIRCKAV HVNHGFGLTWELENKALEEGNYFEM STYSTNRTMIRILFAFVSSVARNDT GYYTCSSSKHPSQSALVTIVEKGFI NATNSSEDYEIDQYEEFCFSVRFKA YPQIRCTWTFSRKSFPCEQKGLDNG YSISKFCNHKHQPGEYIFHAENDDA QFTKMFTLNIRRKPQVLAEASASQA SCFSDGYPLPSWTWKKCSDKSPNCT EEITEGVWNRKANRKVFGQWVSSST LNMSEAIKGFLVKCCAYNSLGTSCE TILLNSPGPFPFIQDNISFYATIGV CLLFIVVLTLLICHKYKKQFRYESQ LQMVQVTGSSDNEYFYVDFREYEYD LKWEFPRENLEFGKVLGSGAFGKVM NATAYGISKTGVSIQVAVKMLKEKA DSSEREALMSELKMMTQLGSHENIV NLLGACTLSGPIYLIFEYCCYGDLL NYLRSKREKFHRTWTEIFKEHNFSF YPTFQSHPNSSMPGSREVQIHPDSD QISGLHGNSFHSEDEIEYENQKRLE EEEDLNVLTFEDLLCFAYQVAKGME FLEFKSCVHRDLAARNVLVTHGKVV KICDFGLARDIMSDSNYVVRGNARL PVKWMAPESLFEGIYTIKSDVWSYG ILLWEIFSLGVNPYPGIPVDANFYK LIQNGFKMDQPFYATEEIYIIMQSC WAFDSRKRPSFPNLTSFLGCQLADA EEAMYQNVDGRVSECPHTYQNRRPF SREMDLGLLSPQAQVEDSTRTRPLE QKLISEEDLAANDILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | FLT3 fms related receptor tyrosine kinase 3 [ Homo sapiens (human) ] |
Official Symbol : | FLT3 |
Synonyms : | FLT3; fms related receptor tyrosine kinase 3; CD135; FLK-2; FLK2; STK1; receptor-type tyrosine-protein kinase FLT3; CD135 antigen; FL cytokine receptor; fetal liver kinase 2; fms related tyrosine kinase 3; fms-like tyrosine kinase 3; growth factor receptor tyrosine kinase type III; stem cell tyrosine kinase 1; EC 2.7.10.1 |
Gene ID : | 2322 |
mRNA Refseq : | NM_004119 |
Protein Refseq : | NP_004110 |
MIM : | 136351 |
UniProt ID : | P36888 |
Products Types
◆ Recombinant Protein | ||
FLT3-2340H | Recombinant Human FLT3 Protein, MYC/DDK-tagged | +Inquiry |
FLT3-1507C | Recombinant Cynomolgus FLT3 protein, hFc-tagged | +Inquiry |
FLT3-6334H | Recombinant Human FLT3 protein, His-tagged | +Inquiry |
FLT3-1155R | Recombinant Rhesus Monkey FLT3 Protein, His-tagged | +Inquiry |
Flt3-10555M | Recombinant Mouse Flt3 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
FLT3-970MCL | Recombinant Mouse FLT3 cell lysate | +Inquiry |
FLT3-2561HCL | Recombinant Human FLT3 cell lysate | +Inquiry |
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Not For Human Consumption!
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Customer Reviews (3)
Write a reviewExcellent product, great price.
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Q&As (7)
Ask a questionFLT3 is frequently mutated in AML, contributing to uncontrolled cell growth and poor prognosis.
FLT3 is predominantly expressed in hematopoietic stem cells and progenitor cells.
It is essential for hematopoiesis, particularly in the proliferation of early progenitor cells.
Therapeutic strategies include FLT3 inhibitors, showing effectiveness in treating AML patients with FLT3 mutations.
FLT3 is a receptor tyrosine kinase that plays a crucial role in cell survival, proliferation, and differentiation.
It stimulates the proliferation and differentiation of hematopoietic stem cells, guiding their development into various blood cell types.
Common mutations include internal tandem duplications (ITD) and tyrosine kinase domain (TKD) mutations, leading to constitutive activation of FLT3.
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