Creative BioMart to Present at BPS 2025 Annual Meeting | February 15-19, 2025

Recombinant Human FLT3 Protein, MYC/DDK-tagged, C13 and N15-labeled

Cat.No. : FLT3-088H
Product Overview : FLT3 MS Standard C13 and N15-labeled recombinant protein (NP_004110) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
  • Specification
  • Gene Information
  • Related Products
  • Download
Description : This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
Source : HEK293
Species : Human
Tag : Myc&DDK
Molecular Mass : 112.7 kDa
AA Sequence : MPALARGGGQLPLLVVFSAMIFGTI TNQDLPVIKCVLINHKNNDSSVGKS SSYPMVSESPEDLGCALRPQSSGTV YEAAAVEVDVSASITLQVLVDAPGN ISCLWVFKHSSLNCQPHFDLQNRGV VSMVILKMTETQAGEYLLFIQSEAT NYTILFTVSIRNTLLYTLRRPYFRK MENQDALVCISESVPEPIVEWVLCD SQGESCKEESPAVVKKEEKVLHELF GMDIRCCARNELGRECTRLFTIDLN QTPQTTLPQLFLKVGEPLWIRCKAV HVNHGFGLTWELENKALEEGNYFEM STYSTNRTMIRILFAFVSSVARNDT GYYTCSSSKHPSQSALVTIVEKGFI NATNSSEDYEIDQYEEFCFSVRFKA YPQIRCTWTFSRKSFPCEQKGLDNG YSISKFCNHKHQPGEYIFHAENDDA QFTKMFTLNIRRKPQVLAEASASQA SCFSDGYPLPSWTWKKCSDKSPNCT EEITEGVWNRKANRKVFGQWVSSST LNMSEAIKGFLVKCCAYNSLGTSCE TILLNSPGPFPFIQDNISFYATIGV CLLFIVVLTLLICHKYKKQFRYESQ LQMVQVTGSSDNEYFYVDFREYEYD LKWEFPRENLEFGKVLGSGAFGKVM NATAYGISKTGVSIQVAVKMLKEKA DSSEREALMSELKMMTQLGSHENIV NLLGACTLSGPIYLIFEYCCYGDLL NYLRSKREKFHRTWTEIFKEHNFSF YPTFQSHPNSSMPGSREVQIHPDSD QISGLHGNSFHSEDEIEYENQKRLE EEEDLNVLTFEDLLCFAYQVAKGME FLEFKSCVHRDLAARNVLVTHGKVV KICDFGLARDIMSDSNYVVRGNARL PVKWMAPESLFEGIYTIKSDVWSYG ILLWEIFSLGVNPYPGIPVDANFYK LIQNGFKMDQPFYATEEIYIIMQSC WAFDSRKRPSFPNLTSFLGCQLADA EEAMYQNVDGRVSECPHTYQNRRPF SREMDLGLLSPQAQVEDSTRTRPLE QKLISEEDLAANDILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
Gene Name : FLT3 fms related receptor tyrosine kinase 3 [ Homo sapiens (human) ]
Official Symbol : FLT3
Synonyms : FLT3; fms related receptor tyrosine kinase 3; CD135; FLK-2; FLK2; STK1; receptor-type tyrosine-protein kinase FLT3; CD135 antigen; FL cytokine receptor; fetal liver kinase 2; fms related tyrosine kinase 3; fms-like tyrosine kinase 3; growth factor receptor tyrosine kinase type III; stem cell tyrosine kinase 1; EC 2.7.10.1
Gene ID : 2322
mRNA Refseq : NM_004119
Protein Refseq : NP_004110
MIM : 136351
UniProt ID : P36888

Not For Human Consumption!

Inquiry

  • Reviews
  • Q&As

Customer Reviews (3)

Write a review
Reviews
08/01/2021

    Excellent product, great price.

    12/22/2020

      Satisfied, will order again.

      09/14/2020

        Quick response, helpful service.

        Q&As (7)

        Ask a question
        How is FLT3 implicated in acute myeloid leukemia (AML)? 12/24/2021

        FLT3 is frequently mutated in AML, contributing to uncontrolled cell growth and poor prognosis.

        In which cells or tissues is FLT3 predominantly expressed? 07/08/2021

        FLT3 is predominantly expressed in hematopoietic stem cells and progenitor cells.

        How does FLT3 contribute to hematopoiesis? 03/15/2021

        It is essential for hematopoiesis, particularly in the proliferation of early progenitor cells.

        Are there therapeutic strategies targeting FLT3 for disease treatment? 08/01/2020

        Therapeutic strategies include FLT3 inhibitors, showing effectiveness in treating AML patients with FLT3 mutations.

        What is the primary biological function of FLT3 in cells? 06/27/2020

        FLT3 is a receptor tyrosine kinase that plays a crucial role in cell survival, proliferation, and differentiation.

        What role does FLT3 play in the proliferation and differentiation of hematopoietic stem cells? 07/14/2019

        It stimulates the proliferation and differentiation of hematopoietic stem cells, guiding their development into various blood cell types.

        What are the common mutations found in FLT3 associated with diseases? 04/05/2019

        Common mutations include internal tandem duplications (ITD) and tyrosine kinase domain (TKD) mutations, leading to constitutive activation of FLT3.

        Ask a Question for All FLT3 Products

        Required fields are marked with *

        My Review for All FLT3 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2025 Creative BioMart. All Rights Reserved.

        Contact Us

        • /
        • Service lnquiry:

        Stay Updated on the Latest Bioscience Trends