- Bacillus subtilis(1)
- Human(8)
- Mouse(1)
- Rhesus Macaque(1)
- Zebrafish(1)
Recombinant Human GALE Protein, Myc/DDK-tagged, C13 and N15-labeled
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| Cat.No. : | GALE-2413H |
| Product Overview : | GALE MS Standard C13 and N15-labeled recombinant protein (NP_001121093) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
| Description : | This gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and cognitive disability, with symptoms ranging from mild ('peripheral' form) to severe ('generalized' form). Multiple alternatively spliced transcripts encoding the same protein have been identified. |
| Source : | HEK293 |
| Species : | Human |
| Tag : | Myc/DDK |
| Molecular Mass : | 38.3 kDa |
| AA Sequence : | MAEKVLVTGG AGYIGSHTVL ELLEAGYLPV VIDNFHNAFR GGGSLPESLR RVQELTGRSV EFEEMDILDQ GALQRLFKKY SFMAVIHFAG LKAVGESVQK PLDYYRVNLT GTIQLLEIMK AHGVKNLVFS SSATVYGNPQ YLPLDEAHPT GGCTNPYGKS KFFIEEMIRD LCQADKTWNA VLLRYFNPTG AHASGCIGED PQGIPNNLMP YVSQVAIGRR EALNVFGNDY DTEDGTGVRD YIHVVDLAKG HIAALRKLKE QCGCRIYNLG TGTGYSVLQM VQAMEKASGK KIPYKVVARR EGDVAACYAN PSLAQEELGW TAALGLDRMC EDLWRWQKQN PSGFGTQATR TRPLEQKLIS EEDLAANDIL DYKDDDDKV |
| Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : | 50 μg/mL as determined by BCA |
| Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
| SDS-PAGE : |
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| Gene Name : | GALE UDP-galactose-4-epimerase [ Homo sapiens (human) ] |
| Official Symbol : | GALE |
| Synonyms : | GALE; UDP-galactose-4-epimerase; galactose 4 epimerase, UDP; UDP-glucose 4-epimerase; SDR1E1; short chain dehydrogenase/reductase family 1E; member 1; UDP glucose 4 epimerase; galactowaldenase; UDP-galactose 4-epimerase; UDP galactose-4-epimerase; galactose-4-epimerase, UDP-; short chain dehydrogenase/reductase family 1E, member 1; FLJ95174; FLJ97302; |
| Gene ID : | 2582 |
| mRNA Refseq : | NM_001127621 |
| Protein Refseq : | NP_001121093 |
| MIM : | 606953 |
| UniProt ID : | Q14376 |
◆ Recombinant Protein
| GALE-4679H | Recombinant Human GALE Protein, GST-tagged | +Inquiry |
| Gale-3136M | Recombinant Mouse Gale Protein, Myc/DDK-tagged | +Inquiry |
| GALE-3741Z | Recombinant Zebrafish GALE | +Inquiry |
| GALE-1804R | Recombinant Rhesus monkey GALE Protein, His-tagged | +Inquiry |
| GALE-1409B | Recombinant Bacillus subtilis GALE protein, His-tagged | +Inquiry |
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◆ Lysates
| GALE-6043HCL | Recombinant Human GALE 293 Cell Lysate | +Inquiry |
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