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Recombinant Human GDF3 Protein, His-tagged

Cat.No. : GDF3-271H
Product Overview : Recombinant Human GDF3(Ala251~Gly364) fused with His tag at N-terminal was expressed in E. coli.
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  • Gene Information
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Description : This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein plays a role ocular and skeletal development. Mutations in this gene are associated with microphthalmia, coloboma, and skeletal abnormalities in human patients.
Source : E. coli
Species : Human
Tag : His
Form : PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Molecular Mass : 14.4kDa
Protein length : Ala251~Gly364
Endotoxin : <1.0EU per 1ug (determined by the LAL method)
Purity : > 95%
Applications : Positive Control; Immunogen; SDS-PAGE; WB.
If bio-activity of the protein is needed, please check active protein
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Reconstitution : Reconstitute in PBS or others
Gene Name : GDF3 growth differentiation factor 3 [ Homo sapiens ]
Official Symbol : GDF3
Synonyms : GDF3; growth differentiation factor 3; growth/differentiation factor 3; GDF-3; KFS3; MCOP7; MCOPCB6;
Gene ID : 9573
mRNA Refseq : NM_020634
Protein Refseq : NP_065685
MIM : 606522
UniProt ID : Q9NR23

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Explain the crosstalk between GDF3 signaling and other cellular pathways. 04/08/2022

GDF3 signaling may crosstalk with Wnt, Notch, and other signaling pathways, modulating their activities and integrating them into a complex regulatory network during development.

Discuss the role of GDF3 in organogenesis and tissue development during embryogenesis. 02/18/2021

GDF3 is implicated in organogenesis, influencing the development of various tissues and organs, including the heart, nervous system, and mesoderm-derived structures.

Explain the post-translational modifications involved in regulating GDF3 activity. 05/27/2020

Post-translational modifications, such as glycosylation and phosphorylation, play roles in regulating GDF3 activity, influencing its stability, secretion, and interaction with receptors.

What are the signaling pathways activated by GDF3, and how do they contribute to cellular processes? 09/11/2019

GDF3 activates the SMAD signaling pathway, influencing cellular processes such as proliferation, differentiation, and apoptosis, especially during early embryonic development.

How is GDF3 involved in the regulation of germ cell development and fertility? 12/15/2018

GDF3 is essential for germ cell development and contributes to the establishment of primordial germ cells, influencing fertility and reproductive success.

Customer Reviews (3)

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Reviews
01/14/2022

    Quick service response—customer support helped us navigate product options.

    06/21/2019

      Speedy delivery! Received this product in excellent condition, ready to use.

      12/07/2018

        This protein's consistent performance is a testament to its quality.

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