Recombinant Human GDF7 Protein, His-tagged

• Cat.No.: GDF7-2200H
• Product Overview: Recombinant Human GDF7 Protein (Thr322-Arg450) with a N-His tag was expressed in E. coli.

Specification

• Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein may play a role in the differentiation of tendon cells and spinal cord interneurons. A mutation in this gene may be associated with increased risk for Barrett's esophagus and esophageal adenocarcinoma.
• Source: E. coli
• Species: Human
• Tag: N-His
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 17.7 kDa
  Accurate Molecular Mass: 18&16 kDa
• Protein length: Thr322-Arg450
• Endotoxin: <1.0 EU per 1µg (determined by the LAL method).
• Purity: > 90%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in PBS or others.

Gene Information

• Gene Name: GDF7 growth differentiation factor 7 [ Homo sapiens (human) ]
• Official Symbol: GDF7
• Synonyms: GDF7; growth differentiation factor 7; growth/differentiation factor 7; BMP12; GDF-7
• Gene ID: 151449
• mRNA Refseq: NM_182828
• Protein Refseq: NP_878248
• MIM: 604651
• UniProt ID: Q7Z4P5