| Description : |
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
63.5 kDa |
| AA Sequence : |
MWTLVSWVALTAGLVAGTRCPDGQF CPVACCLDPGGASYSCCRPLLDKWP TTLSRHLGGPCQVDAHCSAGHSCIF TVSGTSSCCPFPEAVACGDGHHCCP RGFHCSADGRSCFQRSGNNSVGAIQ CPDSQFECPDFSTCCVMVDGSWGCC PMPQASCCEDRVHCCPHGAFCDLVH TRCITPTGTHPLAKKLPAQRTNRAV ALSSSVMCPDARSRCPDGSTCCELP SGKYGCCPMPNATCCSDHLHCCPQD TVCDLIQSKCLSKENATTDLLTKLP AHTVGDVKCDMEVSCPDGYTCCRLQ SGAWGCCPFTQAVCCEDHIHCCPAG FTCDTQKGTCEQGPHQVPWMEKAPA HLSLPDPQALKRDVPCDNVSSCPSS DTCCQLTSGEWGCCPIPEAVCCSDH QHCCPQGYTCVAEGQCQRGSEIVAG LEKMPARRASLSHPRDIGCDQHTSC PVGQTCCPSLGGSWACCQLPHAVCC EDRQHCCPAGYTCNVKARSCEKEVV SAQPATFLARSPHVGVKDVECGEGH FCHDNQTCCRDNRQGWACCPYRQGV CCADRRHCCPAGFRCAARGTKCLRR EAPRWDAPLRDPALRQLLTRTRPLE QKLISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
