Recombinant Human Growth Differentiation Factor 9

• Cat.No.: GDF9-245H
• Product Overview: Recombinant human GDF-9 produced inE.coliis a 31.0 kDa non-disulfide-linked homodimer containing two 135 amino acid polypeptide chains.

Specification

• Cat. No.: GDF9-245H
• Description: GDF-9 is a member of the TGF-β superfamily of growth and differentiation factors, and is highly homologous to GDF-3. Unlike most TGF-family members, GDF-9 and GDF-3 are not disulfide-linked dimers. GDF-3 is expressed in adult bone marrow, spleen, thymus, and adipose tissue. GDF-9 is expressed in oocytes and is required for normal ovarian folliculogenesis.
• Source: E.coli.
• Purity: > 98% by SDS-PAGE and HPLC analysis.
• Endotoxin level: < 0.1 ng per μg of GDF-9.
• Stabilizer: None.
• Formulation: Lyophilized.
• Biologically Activity: Testing in progress.
• Reconstitution: The human GDF-9 should be reconstituted in water to a concentration of 0.1-1.0 mg/ml. This solution can be diluted in water or other buffer solutions or stored at -20℃.
• Stability: The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20°C. Reconstituted human GDF-9 should be stored in working aliquots at -20°C. Avoid repeated freeze-thaw cycles.
• Tag: Non

Gene Information

• Gene Name: GDF9 growth differentiation factor 9 [ Homo sapiens ]
• Synonyms: GDF9; growth differentiation factor 9; OTTHUMP00000066213; Growth/differentiation factor 9; GDF-9
• Gene ID: 2661
• mRNA Refseq: NM_005260
• Protein Refseq: NP_005251
• MIM: 601918
• UniProt ID: O60383
• Chromosome Location: 5q31.1
• Function: cytokine activity; growth factor activity

Reviews

11/14/2021

Expertise in peptide synthesis, accelerates our peptide-related projects.

08/24/2020

Swift protein quantification, improves data reliability in our experiments.

01/31/2019

Outstanding protein-protein interaction studies, boost our research efforts.

Q&As

How does GDF9 influence the proliferation and differentiation of granulosa cells in the ovary?

GDF9 stimulates granulosa cell proliferation and differentiation, essential for healthy ovarian function.

What are the mechanisms by which GDF9 modulates intra-ovarian signaling pathways?

GDF9 interacts with intra-ovarian signaling pathways, coordinating follicle development and ovulation.

How do alterations in GDF9 expression or function affect embryonic development and early pregnancy?

Changes in GDF9 expression impact embryonic development and the success of early pregnancy stages.

What role does GDF9 play in fertility and reproductive outcomes in females?

GDF9 significantly impacts female fertility, affecting egg quality and reproductive potential.

What is the impact of GDF9 mutations on the pathogenesis of ovarian dysfunctions and disorders?

Mutations in GDF9 can lead to ovarian disorders, impacting follicle development and female fertility.

How does GDF9 regulate ovarian follicle development and oocyte maturation?

GDF9 is crucial for ovarian follicle growth and oocyte maturation, influencing female fertility.

How does GDF9 contribute to the regulation of steroidogenesis in ovarian cells?

GDF9 regulates steroid hormone production in ovarian cells, influencing reproductive hormone balance.