Recombinant Human GSK3B Protein, MYC/DDK-tagged, C13 and N15-labeled

• Cat.No.: GSK3B-012H
• Product Overview: GSK3B MS Standard C13 and N15-labeled recombinant protein (NP_002084) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. Defects in this gene have been associated with Parkinson disease and Alzheimer disease.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 47.9 kDa
• AA Sequence: MSGRPRTTSFAESCKPVQQPSAFGS MKVSRDKDGSKVTTVVATPGQGPDR PQEVSYTDTKVIGNGSFGVVYQAKL CDSGELVAIKKVLQDKRFKNRELQI MRKLDHCNIVRLRYFFYSSGEKKDE VYLNLVLDYVPETVYRVARHYSRAK QTLPVIYVKLYMYQLFRSLAYIHSF GICHRDIKPQNLLLDPDTAVLKLCD FGSAKQLVRGEPNVSYICSRYYRAP ELIFGATDYTSSIDVWSAGCVLAEL LLGQPIFPGDSGVDQLVEIIKVLGT PTREQIREMNPNYTEFKFPQIKAHP WTKDSSGTGHFTSGVRVFRPRTPPE AIALCSRLLEYTPTARLTPLEACAH SFFDELRDPNVKLPNGRDTPALFNF TTQELSSNPPLATILIPPHARIQAA ASTPTNATAASDANTGDRGQTNNAA SASASNSTTRTRPLEQKLISEEDLA ANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: GSK3B glycogen synthase kinase 3 beta [ Homo sapiens (human) ]
• Official Symbol: GSK3B
• Synonyms: GSK3B; glycogen synthase kinase 3 beta; glycogen synthase kinase-3 beta; glycogen synthase kinase 3 beta; GSK3beta isoform; glycogen synthase kinase-3 beta; GSK-3 beta; serine/threonine-protein kinase GSK3B; EC 2.7.11.1; EC 2.7.11.26
• Gene ID: 2932
• mRNA Refseq: NM_002093
• Protein Refseq: NP_002084
• MIM: 605004
• UniProt ID: P49841