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Active Recombinant Human HDAC5 Protein

Cat.No. : HDAC5-312H
Product Overview : Recombinant Human HDAC5 Protein is produced by HEK293 cells expression system.
  • Specification
  • Gene Information
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Description : Human HDAC5 is composed of 1122 amino acid residues. The deacetylase domain of HDAC5 is located at the C-terminal half of the molecule. The N-terminal non-deacetylase domain does not show any significant homology with any published sequence. Both domains are required for HDAC5-mediated repression of gene transcription. HDAC5 interacts with a growing number of transcriptional factors including MEF2A as well as other HDAC proteins. The interacting complexes bind to specific regions of chromatin and regulate gene transcription in these regions.
Source : HEK293 cells
Species : Human
Form : Liquid, In 30 mM HEPES, 140 mM NaCl, 10 mM KCl, 3% glycerol, 0.25 mM TCEP, pH 7.6.
Bio-activity : Deacetylation activity was determined using the Boc-K(TFA)-AMC substrate. Reactions were carried out in a 384-well plate in 20 µL of reaction buffer comprising of 50 mM HEPES, 140 mM NaCl, 10 mM KCl, 1 mg/ml bovine serum albumin (BSA), and 1 mM TCEP, pH 7.4, for 30 min at 37°C. The reaction was stopped by addition of 20 µl of trypsin solution (2 mg/ml trypsin) and the fluorescence signal of released AMC was quantified using a fluorometer. The enzyme kinetic values were calculated by nonlinear regression analysis.
Molecular Mass : 45 kDa
Protein length : amino acids 679-1095
Purity : ≥95% by SDS-PAGE
Notes : For Research Use Only! Not For Use in Humans.
Storage : Store at -80 centigrade.
Handling : Thaw on ice, and aliquot into smaller working quantities to avoid multiple freeze/thaw cycles.
Gene Name : HDAC5 histone deacetylase 5 [ Homo sapiens ]
Official Symbol : HDAC5
Synonyms : HDAC5; histone deacetylase 5; FLJ90614; KIAA0600; NY CO 9; antigen NY-CO-9; HD5; NY-CO-9;
Gene ID : 10014
mRNA Refseq : NM_001015053
Protein Refseq : NP_001015053
MIM : 605315
UniProt ID : Q9UQL6

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Is there a relationship between HDAC5 and neurological diseases? 11/26/2022

It has been linked to a variety of neurological diseases, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, etc. It influences the development of these diseases by regulating the function and survival of neurons.

What is the link between HDAC5 and cardiovascular disease? 04/17/2022

This is also associated with cardiovascular disease. Studies have shown that HDAC5 can regulate the function and survival of the heart, influencing the development of heart disease.

What is the relationship between HDAC5 and disease? 04/17/2022

HDAC5 is associated with a variety of diseases, including cancer, neurological diseases, cardiovascular diseases, etc.

How is HDAC5 activity regulated? 02/08/2021

The activity of HDAC5 is regulated by a variety of factors, including intracellular signaling, transcription factors, and other proteases.

Do HDAC5 inhibitors have a role in treatment? 07/07/2020

HDAC5 inhibitors can enhance the sensitivity of tumor cells and improve the effectiveness of chemotherapy or radiotherapy. In addition, it can also inhibit the migration and invasion of tumor cells.

Which role of HDAC5 in cancer? 01/21/2020

This protein plays an important role in cancer, affecting the occurrence and progression of tumors by regulating the expression of tumor suppressor genes and tumor progenes.

Customer Reviews (3)

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Reviews
02/22/2022

    The HDAC5 they produce is of guaranteed quality, and we can rest assured that we buy it.

    12/22/2021

      It performs well in ELISA and is very suitable for immunoassays.

      02/13/2020

        It has strong antibacterial activity and is not easy to be contaminated.

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