Active Recombinant Human HDAC5 Protein
Cat.No. : | HDAC5-312H |
Product Overview : | Recombinant Human HDAC5 Protein is produced by HEK293 cells expression system. |
- Specification
- Gene Information
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Description : | Human HDAC5 is composed of 1122 amino acid residues. The deacetylase domain of HDAC5 is located at the C-terminal half of the molecule. The N-terminal non-deacetylase domain does not show any significant homology with any published sequence. Both domains are required for HDAC5-mediated repression of gene transcription. HDAC5 interacts with a growing number of transcriptional factors including MEF2A as well as other HDAC proteins. The interacting complexes bind to specific regions of chromatin and regulate gene transcription in these regions. |
Source : | HEK293 cells |
Species : | Human |
Form : | Liquid, In 30 mM HEPES, 140 mM NaCl, 10 mM KCl, 3% glycerol, 0.25 mM TCEP, pH 7.6. |
Bio-activity : | Deacetylation activity was determined using the Boc-K(TFA)-AMC substrate. Reactions were carried out in a 384-well plate in 20 µL of reaction buffer comprising of 50 mM HEPES, 140 mM NaCl, 10 mM KCl, 1 mg/ml bovine serum albumin (BSA), and 1 mM TCEP, pH 7.4, for 30 min at 37°C. The reaction was stopped by addition of 20 µl of trypsin solution (2 mg/ml trypsin) and the fluorescence signal of released AMC was quantified using a fluorometer. The enzyme kinetic values were calculated by nonlinear regression analysis. |
Molecular Mass : | 45 kDa |
Protein length : | amino acids 679-1095 |
Purity : | ≥95% by SDS-PAGE |
Notes : | For Research Use Only! Not For Use in Humans. |
Storage : | Store at -80 centigrade. |
Handling : | Thaw on ice, and aliquot into smaller working quantities to avoid multiple freeze/thaw cycles. |
Gene Name : | HDAC5 histone deacetylase 5 [ Homo sapiens ] |
Official Symbol : | HDAC5 |
Synonyms : | HDAC5; histone deacetylase 5; FLJ90614; KIAA0600; NY CO 9; antigen NY-CO-9; HD5; NY-CO-9; |
Gene ID : | 10014 |
mRNA Refseq : | NM_001015053 |
Protein Refseq : | NP_001015053 |
MIM : | 605315 |
UniProt ID : | Q9UQL6 |
Products Types
◆ Recombinant Protein | ||
HDAC5-4647H | Recombinant Human HDAC5 Protein, GST-tagged | +Inquiry |
HDAC5-48H | Recombinant Human HDAC5 Protein, His-tagged | +Inquiry |
HDAC5-164H | Recombinant Human HDAC5 Protein, His-tagged | +Inquiry |
HDAC5-1876R | Recombinant Rhesus Macaque HDAC5 Protein, His (Fc)-Avi-tagged | +Inquiry |
HDAC5-96H | Active Recombinant Human HDAC5 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
HDAC5-5604HCL | Recombinant Human HDAC5 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-1741 | HDAC5 Fluorogenic Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionIt has been linked to a variety of neurological diseases, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, etc. It influences the development of these diseases by regulating the function and survival of neurons.
This is also associated with cardiovascular disease. Studies have shown that HDAC5 can regulate the function and survival of the heart, influencing the development of heart disease.
HDAC5 is associated with a variety of diseases, including cancer, neurological diseases, cardiovascular diseases, etc.
The activity of HDAC5 is regulated by a variety of factors, including intracellular signaling, transcription factors, and other proteases.
HDAC5 inhibitors can enhance the sensitivity of tumor cells and improve the effectiveness of chemotherapy or radiotherapy. In addition, it can also inhibit the migration and invasion of tumor cells.
This protein plays an important role in cancer, affecting the occurrence and progression of tumors by regulating the expression of tumor suppressor genes and tumor progenes.
Customer Reviews (3)
Write a reviewThe HDAC5 they produce is of guaranteed quality, and we can rest assured that we buy it.
It performs well in ELISA and is very suitable for immunoassays.
It has strong antibacterial activity and is not easy to be contaminated.
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