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Recombinant Human IL18BP protein, Fc-tagged
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Cat.No. : | IL18BP-162H Optional Service: Optional requirements on this protein |
Product Overview : | Recombinant Human IL18BP (Thr31-Gly194) protein was fused to human IgG1 Fc tag at C-terminus and expressed in human 293 cells (HEK293). |
Description : | Interleukin-18-binding protein (IL18BP) is also known as Tadekinig-alfa, IL18BPa, which functions as an IL18 inhibitor. IL18BP is a secreted protein which contains one Ig-like C2-type (immunoglobulin-like) domain. IL18BP does not have a transmembrane domain and hence is not anchored to the cell membrane. IL18BP is strongly expressed in heart, lung, placenta and spleen. Isoform A of IL18BP binds to IL-18 and inhibits its activity. IL18BP also functions as an inhibitor of the early TH1 cytokine response. IL18BP suppresses the production of IFN-gamma resulting in reduced T-helper type 1 immune responses. |
Source : | HEK293 |
Species : | Human |
Tag : | human IgG1 Fc |
Predicted N Terminal : | Thr31 |
Form : | Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5, 10% trehalose. |
Molecular Mass : | The protein has a calculated MW of 44.3 kDa. The protein migrates as 56-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Protein length : | Thr31-Gly194 |
Endotoxin : | Less than 1.0 EU per μg by the LAL method. |
Purity : | >95% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents. |
SDS-PAGE of IL18BP-162H : |
![]() Human IL-18BP, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. |
Gene Name : | IL18BP |
Official Symbol : | IL18BP |
Synonyms : | IL18BP; interleukin 18 binding protein; interleukin-18-binding protein; IL18BPa; MC51L 53L 54L homolog gene product; IL-18BP; tadekinig-alfa; MC51L-53L-54L homolog gene product |
Gene ID : | 10068 |
mRNA Refseq : | NM_001039659 |
Protein Refseq : | NP_001034748 |
MIM : | 604113 |
UniProt ID : | O95998 |
◆ Recombinant Protein
IL18BP-75H | Recombinant Human IL18BP Protein | +Inquiry |
IL18BP-194H | Recombinant Human IL18BP Protein, His (Fc)-Avi-tagged | +Inquiry |
Il18bp-10579M | Recombinant Mouse Il18bp Protein, His (Fc)-Avi-tagged | +Inquiry |
IL18BP-252I | Recombinant Human IL18BP Protein | +Inquiry |
Il18bp-142M | Recombinant Mouse Il18bp Protein, His (Fc)-Avi-tagged | +Inquiry |
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◆ Lysates
IL18BP-2674MCL | Recombinant Mouse IL18BP cell lysate | +Inquiry |
IL18BP-2918HCL | Recombinant Human IL18BP cell lysate | +Inquiry |
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