Recombinant Human IL20RA Protein, His-tagged

• Cat.No.: IL20RA-968H
• Product Overview: Recombinant Human IL20RA(Val30-Lys250) fused with His tag at N-terminal was expressed in HEK293 cells.

Specification

• Description: This gene encodes a member of the type II cytokine receptor family. The encoded protein is a subunit of the receptor for interleukin 20, a cytokine that may be involved in epidermal function. The interleukin 20 receptor is a heterodimeric complex consisting of the encoded protein and interleukin 20 receptor beta. This gene and interleukin 20 receptor beta are highly expressed in skin, and are upregulated in psoriasis. Alternative splicing results in multiple transcript variants.
• Source: HEK293 cells
• Tag: His
• Form: Lyophilized from a 0.2 µM filtered solution of 20mM Phosphate buffer, 150mM NaCl, pH 7.4. Stable for at least 6 months from date of receipt under proper storage and handling conditions.
• Molecular Mass: 26.3 kDa
• Endotoxin: < 0.1 EU per µg protein as determined by LAL test
• Purity: >95% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: Resuspend the protein to the desired concentration in proper buffer.
• Protein length: Val30-Lys250

Gene Information

• Gene Name: IL20RA interleukin 20 receptor, alpha [ Homo sapiens ]
• Official Symbol: IL20RA
• Synonyms: IL20RA; interleukin 20 receptor, alpha; interleukin-20 receptor subunit alpha; IL 20R1; ZCYTOR7; CRF2-8; IL-20RA; IL-20R-alpha; interleukin-20 receptor I; IL-20 receptor subunit alpha; class II cytokine receptor ZCYTOR7; cytokine receptor class-II member 8; cytokine receptor family 2 member 8; IL-20R1; FLJ40993
• Gene ID: 53832
• mRNA Refseq: NM_014432
• Protein Refseq: NP_055247
• MIM: 605620
• UniProt ID: Q9UHF4

Reviews

07/12/2021

Good for signaling studies.

10/13/2017

High specificity.

10/03/2016

Effective in skin models.

Q&As

What is the impact of IL20RA on cytokine secretion?

IL20RA increases IL-17 and IL-22 production.

Does IL20RA expression correlate with disease severity in psoriasis?

IL20RA expression correlates with disease severity in psoriasis.

What is IL20RA's role in autoimmune diseases?

IL20RA is implicated in autoimmune diseases like psoriasis.

How does IL20RA modulate skin inflammation?

IL20RA modulates skin inflammation by activating keratinocytes.

How does IL20RA expression change in cancerous tissues?

IL20RA expression is upregulated in melanoma.

How does IL20RA influence the JAK-STAT signaling pathway?

IL20RA activates the JAK-STAT signaling pathway.

Does IL20RA interact with other interleukin receptors?

IL20RA interacts with IL-20 and IL-24 receptors.

How does IL20RA affect T-cell differentiation?

IL20RA induces Th17 cell differentiation.

Does IL20RA have a role in cell migration?

IL20RA promotes keratinocyte migration.

What post-translational modifications occur on IL20RA?

IL20RA undergoes phosphorylation.