Recombinant Human IL3RA Protein, Fc-tagged, Alexa Fluor 647 conjugated
Cat.No. : | IL3RA-29795THAF647 |
Product Overview : | Alexa Fluor 647 conjugated recombinant fragment, corresponding to amino acids 19-302 of Human IL3RA fused to the Fc region of human IgG1 expressed in modified human 293 cells, 533 amino acids, Predicted MWt 60.6 kDa. |
Availability | July 26, 2024 |
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Description : | The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. |
Source : | HEK293 |
Species : | Human |
Tag : | Fc |
Form : | Lyophilized |
N-terminal Sequence Analysis : | TKEDPNPPITNLRMKAKAQQLTWDL NRNVTDIECVKDADY SMPAVNNSYCQFGAISLCEVTNYTV RVANPPFSTWILF PENSGKPWAGAENLTCWIHDVDFLS CSWAVGPGAPADV QYDLYLNVANRRQQYECLHYKTDAQ GTRIGCRFDDISR LSSGSQSSHILVRGRSAAFGIPCTD KFVVFSQIEILTP PNMTAKCNKTHSFMHWKMRSHFNRK FRYELQIQKRMQPVITEQVRDRTSF QLLNPGTYTVQIRARERVYEFLSAW STP QRFECDQEEGANTRGGRVDGIQWIP KVDKKVEPKSCDK THTCPPCPAPELLGGPSVFLFPPKP KDTLMISRTPEVT CVVVDVSHEDPEVKFNWYVDGVEVH NAKTKPREEQYNS TYRVVSVLTVLHQDWLNGKEYKCRV SNKALPAPIEKTI SKAKGQPREPQVYTLPPSRDELTKN QVSLTCLVKGFYPSDIAVEWESNGQ PENNYKTTPPVLDSDGSFFLYSKLT VDK SRWQQGNVFSCSVMHEALHNHYTQK SLSLSPGK |
Purity : | > 95 % as determined by SDS-PAGE |
Characteristic : | Disulfide-linked homodimer Labeled with Alexa Fluor 647 via amines Excitation = 650 nm Emission = 668 nm |
Storage : | Store at +4 centigrade. |
Storage Buffer : | 10% Trehalose, 1% Human serum albumin |
Reconstitution : | It is recommended that 0.5 mL of sterile phosphate-buffered saline be added to the vial. Following reconstitution short-term storage at 4 centigrade is recommended, with longer-term storage in aliquots at -18 to -20 centigrade. Repeated freeze thawing is not recommended. |
Gene Name : | IL3RA interleukin 3 receptor, alpha (low affinity) [ Homo sapiens ] |
Official Symbol : | IL3RA |
Synonyms : | IL3RA; interleukin 3 receptor, alpha (low affinity); interleukin-3 receptor subunit alpha; CD123; |
Gene ID : | 3563 |
mRNA Refseq : | NM_002183 |
Protein Refseq : | NP_002174 |
MIM : | 308385 |
UniProt ID : | P26951 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewIn special environment, good stability.
Good crystallization property and good effect.
Has the expected biological activity, such as enzyme activity and receptor binding activity, and so on.
Q&As (6)
Ask a questionThe feasibility of personalized therapy depends on the specific disease type and patient situation, and more research is needed to determine the application of personalized therapy to Il3ra.
Il3ra has certain promise in clinical application, especially in the treatment of immune-related diseases.
Regulates the proliferation and differentiation of immune cells by binding to its interacting cytokine IL-3, and plays a role in regulating the function of the immune system.
Clinical trials of recombinant Il3ra have been conducted in different disease areas. At present, some early trials show its potential in the treatment of certain diseases, but more research is needed to verify its efficacy and safety.
The Il3ra can regulate the proliferation and differentiation of different types of immune cells in the immune system, thus affecting the function of the immune system.
Il3ra is generally well tolerated, but some minor side effects such as headache and nausea may occur. Serious side effects are rare.
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