Active Recombinant Human IL6RA protein
Cat.No. : | IL6RA-3322H |
Product Overview : | Recombinant Human IL6RA Protein is produced by HEK293 cells expression system. |
- Specification
- Gene Information
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Description : | IL-6 mediates its biological effects through the type I IL-6 receptor system that consists of two chains, IL-6Rα and gp130. While the IL-6Rα chain is the binding component specific to IL-6, the gp130 chain only transmits signals of IL-6 when bound to IL-6Rα. The gp130 can also transmit signals from LIF, OSM, CNTF, IL-11 and CT-1 in conjunction with other receptor subunits. The low-affinity binding site for IL-6 is composed of IL-6Rα alone. IL-6Rα is expressed in a wide range of cells, including T cells, fibroblasts and macrophages. Soluble IL-6Rα, which consists of only the extracellular domain of the IL-6Rα chain, acts as an agonist of IL-6 activity at low concentrations. Recombinant Human sIL-6Rα is a 37.6 kDa protein consisting of the extracellular domain of the IL-6Rα chain (339 amino acid residues). |
Source : | HEK293 cells |
Species : | Human |
Bio-activity : | The ED50 was determined by its ability to intensify the IL-6 induced growth inhibition of murine M1 cells is ≤ 5.0 ng/ml, in the presence of 20 ng/ml of rhIL-6. |
Molecular Mass : | 37.6 kDa |
AA Sequence : | LAPRRCPAQE VARGVLTSLP GDSVTLTCPG VEPEDNATVH WVLRKPAAGS HPSRWAGMGR RLLLRSVQLH DSGNYSCYRA GRPAGTVHLL VDVPPEEPQL SCFRKSPLSN VVCEWGPRST PSLTTKAVLL VRKFQNSPAE DFQEPCQYSQ ESQKFSCQLA VPEGDSSFYI VSMCVASSVG SKFSKTQTFQ GCGILQPDPP ANITVTAVAR NPRWLSVTWQ DPHSWNSSFY RLRFELRYRA ERSKTFTTWM VKDLQHHCVI HDAWSGLRHV VQLRAQEEFG QGEWSEWSPE AMGTPWTESR SPPAENEVST PMQALTTNKD DDNILFRDSA NATSLPVQD |
Purity : | ≥ 98% by SDS-PAGE gel and HPLC analyses. |
Notes : | Not for human use. |
Synonyms : | soluble IL-6 receptor alpha; B cell stimulatory factor-2; CD126; |
Synonyms : | soluble IL-6 receptor alpha; B cell stimulatory factor-2; CD126; |
Products Types
◆ Recombinant Protein | ||
IL6RA-4520M | Recombinant Mouse IL6RA Protein, His (Fc)-Avi-tagged | +Inquiry |
IL6RA-3324H | Active Recombinant Human IL6RA protein | +Inquiry |
Il6ra-1246M | Recombinant Mouse Il6ra Protein, MYC/DDK-tagged | +Inquiry |
Il6ra-583M | Recombinant Mouse Il6ra protein, His-tagged | +Inquiry |
IL6RA-8178M | Recombinant Mouse IL6RA Protein | +Inquiry |
◆ Lysates | ||
IL6R-2590MCL | Recombinant Mouse IL6R cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionIl6ra blocks the binding of the interleukin-6 receptor by acting on it, thereby affecting its immunomodulatory effect and reducing inflammation.
The efficacy of Il6ra is related to the severity of the disease, disease type and individual differences of patients, and should be judged by professional physicians according to the situation.
Il6ra can be used to treat rheumatoid arthritis, psoriasis, alopecia areata and other autoimmune diseases.
Almost all treatments have some kind of side effect, but the occurrence of side effects can be reduced with proper dosing and monitoring.
Recombinant Il6ra inhibits the immune response by inhibiting the cytokine activity of interleukin-6.
In addition to the autoimmune diseases mentioned above, Il6ra may also be used in the future to treat chronic inflammatory bowel disease, neurodegenerative diseases, and cancer.
Customer Reviews (3)
Write a reviewIt has good effect and stability in gene expression regulation.
Will not interact with other drugs, will not affect.
The application performance is stable in common colorimetric reactions.
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