Recombinant Human INPP5D Protein, Myc/DDK-tagged, C13 and N15-labeled

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Recombinant Human INPP5D Protein, Myc/DDK-tagged, C13 and N15-labeled

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Cat.No. : INPP5D-5966H
Product Overview : INPP5D MS Standard C13 and N15-labeled recombinant protein (NP_005532) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
Description : This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 133 kDa
AA Sequence : MVPCWNHGNI TRSKAEELLS RTGKDGSFLV RASESISRAY ALCVLYRNCV YTYRILPNED DKFTVQASEG VSMRFFTKLD QLIEFYKKEN MGLVTHLQYP VPLEEEDTGD DPEEDTESVV SPPELPPRNI PLTASSCEAK EVPFSNENPR ATETSRPSLS ETLFQRLQSM DTSGLPEEHL KAIQDYLSTQ LAQDSEFVKT GSSSLPHLKK LTTLLCKELY GEVIRTLPSL ESLQRLFDQQ LSPGLRPRPQ VPGEANPINM VSKLSQLTSL LSSIEDKVKA LLHEGPESPH RPSLIPPVTF EVKAESLGIP QKMQLKVDVE SGKLIIKKSK DGSEDKFYSH KKILQLIKSQ KFLNKLVILV ETEKEKILRK EYVFADSKKR EGFCQLLQQM KNKHSEQPEP DMITIFIGTW NMGNAPPPKK ITSWFLSKGQ GKTRDDSADY IPHDIYVIGT QEDPLSEKEW LEILKHSLQE ITSVTFKTVA IHTLWNIRIV VLAKPEHENR ISHICTDNVK TGIANTLGNK GAVGVSFMFN GTSLGFVNSH LTSGSEKKLR RNQNYMNILR FLALGDKKLS PFNITHRFTH LFWFGDLNYR VDLPTWEAET IIQKIKQQQY ADLLSHDQLL TERREQKVFL HFEEEEITFA PTYRFERLTR DKYAYTKQKA TGMKYNLPSW CDRVLWKSYP LVHVVCQSYG STSDIMTSDH SPVFATFEAG VTSQFVSKNG PGTVDSQGQI EFLRCYATLK TKSQTKFYLE FHSSCLESFV KSQEGENEEG SEGELVVKFG ETLPKLKPII SDPEYLLDQH ILISIKSSDS DESYGEGCIA LRLEATETQL PIYTPLTHHG ELTGHFQGEI KLQTSQGKTR EKLYDFVKTE RDESSGPKTL KSLTSHDPMK QWEVTSRAPP CSGSSITEII NPNYMGVGPF GPPMPLHVKQ TLSPDQQPTA WSYDQPPKDS PLGPCRGESP PTPPGQPPIS PKKFLPSTAN RGLPPRTQES RPSDLGKNAG DTLPQEDLPL TKPEMFENPL YGSLSSFPKP APRKDQESPK MPRKEPPPCP EPGILSPSIV LTKAQEADRG EGPGKQVPAP RLRSFTCSSS AEGRAAGGDK SQGKPKTPVS SQAPVPAKRP IKPSRSEINQ QTPPTPTPRP PLPVKSPAVL HLQHSKGRDY RDNTELPHHG KHRPEEGPPG PLGRTAMQTR TRPLEQKLIS EEDLAANDIL DYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
SDS-PAGE :

Gene Name : INPP5D inositol polyphosphate-5-phosphatase D [ Homo sapiens (human) ]
Official Symbol : INPP5D
Synonyms : INPP5D; inositol polyphosphate-5-phosphatase, 145kDa; inositol polyphosphate 5 phosphatase, 145kD; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1; hp51CN; SHIP; SHIP-1; p150Ship; SH2 domain-containing inositol phosphatase 1; SH2 containing inositol phosphatase, isoform b; SH2 domain-containing inositol 5-phosphatase 1; SH2 domain-containing inositol-5-phosphatase 1; inositol polyphosphate-5-phosphatase of 145 kDa; signaling inositol polyphosphate 5 phosphatase SIP-145; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1; SHIP1; SIP-145; MGC104855; MGC142140; MGC142142;
Gene ID : 3635
mRNA Refseq : NM_005541
Protein Refseq : NP_005532
MIM : 601582
UniProt ID : Q92835

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