Recombinant Human Interleukin 4 Receptor
Cat.No. : | IL4R-1645H |
- Specification
- Gene Information
- Related Products
Cat. No. : | IL4R-1645H |
Description : | Human IL-4 exerts its biological effects via signaling through its receptor system, IL-4R. There are two types of the IL-4 receptor complexes, the type I receptor consisting of the IL-4R alpha and the common gamma chain, yc and the type II receptor consisting of IL-4R alpha and the IL-13R alpha. The IL-4R alpha chain contains an extracellular domain of 207 amino acids, a transmembrane domain of 24 amino acids, and an intracellular domain of 569 amino acids. |
Source : | Mammalian cells |
State Of Matter : | Lyophilized. |
Purity : | >95% by SDS Page and analyzed by silver stain. |
Endotoxin : | <0.1 ng per 1 µg as determined by the LAL method. |
Molecular Weight : | The predicted molecular weight of Recombinant Human IL-4 R is Mr 50.5 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 75-85 kDa. |
Storage And Stability : | This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. |
Gene Name : | IL4R interleukin 4 receptor [ Homo sapiens ] |
Synonyms : | IL4R; interleukin 4 receptor; CD124; IL4RA; interleukin 4 receptor alpha chain; OTTHUMP00000122506; interleukin-4 receptor alpha chain; CD_antigen; IL-4R-alpha; Soluble interleukin-4 receptor alpha chain; sIL4Ralpha/prot; IL-4-binding protein; IL4-BP |
Gene ID : | 3566 |
mRNA Refseq : | NM_000418 |
Protein Refseq : | NP_000409 |
MIM : | 147781 |
UniProt ID : | P24394 |
Chromosome Location : | 16p12.1-p11.2 |
Pathway : | Cytokine-cytokine receptor interaction; Endocytosis; Hematopoietic cell lineage; Jak-STAT signaling pathway |
Function : | interleukin-4 receptor activity; receptor activity; protein binding; receptor signaling protein activity |
Products Types
◆ Recombinant Protein | ||
IL4R-330C | Recombinant Cynomolgus monkey IL4R Protein, Fc-tagged | +Inquiry |
IL4R-068H | Recombinant Human IL4R Protein, C-His-tagged | +Inquiry |
IL4R-2321H | Recombinant Human IL4R Protein, His-tagged | +Inquiry |
IL4R-4443H | Recombinant Human IL4R Protein, His (Fc)-Avi-tagged | +Inquiry |
IL4R-1382C | Acitve Recombinant Cynomolgus IL4R protein(Met1-Arg232), hFc-tagged | +Inquiry |
◆ Lysates | ||
IL4R-2719HCL | Recombinant Human IL4R cell lysate | +Inquiry |
IL4R-1051RCL | Recombinant Rat IL4R cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionIL4R is a synthetic protein that mimics the IL-4 signaling pathway in nature and binds to the IL-4 receptor in cells, which can be used to study the IL-4 signaling pathway and related diseases.
Common IL4R production technologies include prokaryotic expression systems and mammalian cell expression systems.
This protein is used in tumor immunotherapy, which can promote anti-tumor immune response and enhance the anti-tumor effect of cytotoxic T lymphocytes.
It is mainly used in immunology, drug research and other fields. It is also widely used in vaccines, biotechnology, cancer treatment and so on.
IL4R is used to treat severe pheochromocytome-induced aerodoritis and was approved by the FDA as the first drug to treat this disease.
IL4R cannot generally be administered orally, and needs to be administered by injection or intravenous drip.
Customer Reviews (3)
Write a reviewEasy to attach to the surface of cells or materials.
It has growth factor activity to promote cell growth and proliferation.
In animals or humans caused by the prone production of antibodies.
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