Recombinant Human KAT6A Protein (488-778), N-hFc tagged

• Cat.No.: KAT6A-12H
• Product Overview: Recombinant KAT6A / MOZ (488-778) protein that includes amino acids 488-778 of human KAT6A protein (accession number NP_006757.2) was expressed in a baculovirus expression system and contains an N-terminal FLAG tag. This product is the catalytic domain of KAT6A protein.

Specification

• Description: This gene encodes a member of the MOZ, YBFR2, SAS2, TIP60 family of histone acetyltransferases. The protein is composed of a nuclear localization domain, a double C2H2 zinc finger domain that binds to acetylated histone tails, a histone acetyl-transferase domain, a glutamate/aspartate-rich region, and a serine- and methionine-rich transactivation domain. It is part of a complex that acetylates lysine-9 residues in histone 3, and in addition, it acts as a co-activator for several transcription factors. Allelic variants of this gene are associated with an autosomal dominant form of cognitive disability. Chromosomal translocations of this gene are associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants.
• Source: Baculovirus
• Species: Human
• Tag: N-FLAG
• Molecular Mass: 35.5 kDa
• Protein Length: 488-778
• Purity: > 92 %
• Storage: Recombinant proteins in solution are temperature sensitive and must be stored at -80 centigrade to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
• Concentration: 0.4 μg/μL
• Storage Buffer: 25 mM HEPES-NaOH pH 7.5, 300 mM NaCl, 10 % glycerol, 0.04 % Triton X-100, and 0.5 mM TCEP.

Gene Information

• Gene Name: KAT6A lysine acetyltransferase 6A [ Homo sapiens (human) ]
• Official Symbol: KAT6A
• Synonyms: KAT6A; lysine acetyltransferase 6A; MOZ; ARTHS; MRD32; MYST3; MYST-3; ZNF220; RUNXBP2; ZC2HC6A; histone acetyltransferase KAT6A; K(lysine) acetyltransferase 6A; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3; MYST histone acetyltransferase (monocytic leukemia) 3; histone acetyltransferase MYST3; monocytic leukemia zinc finger protein; runt-related transcription factor binding protein 2; zinc finger protein 220; EC 2.3.1.48
• Gene ID: 7994
• mRNA Refseq: NM_006766
• Protein Refseq: NP_006757
• MIM: 601408