Recombinant Human MAPT protein(1-441 aa)(acetyl K281), C-His-tagged
Cat.No. : | MAPT-2893H |
Product Overview : | Recombinant Human MAPT protein(P10636-8)(1-441 aa)(acetyl K281), fused with C-terminal His tag, was expressed in E. coli. |
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Source : | E. coli |
Species : | Human |
Tag : | His |
Protein length : | 1-441 aa |
Form : | 0.15 M Phosphate buffered saline |
Molecular Mass : | 48 kDa |
AASequence : | MAEPRQEFEVMEDHAGTYGLGDRKD QGGYTMHQDQEGDTDAGLKESPLQT PTEDGSEEPGSETSDAKSTPTAEDV TAPLVDEGAPGKQAAAQPHTEIPEG TTAEEAGIGDTPSLEDEAAGHVTQA RMVSKSKDGTGSDDKKAKGADGKTK IATPRGAAPPGQKGQANATRIPAKT PPAPKTPPSSGEPPKSGDRSGYSSP GSPGTPGSRSRTPSLPTPPTREPKK VAVVRTPPKSPSSAKSRLQTAPVPM PDLKNVKSKIGSTENLKHQPGGGKV QIINKKLDLSNVQSKCGSKDNIKHV PGGGSVQIVYKPVDLSKVTSKCGSL GNIHHKPGGGQVEVKSEKLDFKDRV QSKIGSLDNITHVPGGGNKKIETHK LTFRENAKAKTDHGAEIVYKSPVVS GDTSPRHLSNVSSTGSIDMVDSPQL ATLADEVSASLAKQGL |
Storage : | Shipped on dry ice. Avoid repeated freeze-thaw cycles. Upon receipt, 2 days when stored at 2 to 8 °C after thawing. Up to 12 months when aliquoted and stored at -20 to -80°C. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents. |
Gene Name : | MAPT microtubule-associated protein tau [ Homo sapiens ] |
Official Symbol : | MAPT |
Synonyms : | MAPT; microtubule-associated protein tau; DDPAC, MAPTL; FLJ31424; FTDP 17; G protein beta1/gamma2 subunit interacting factor 1; MGC138549; microtubule associated protein tau; isoform 4; MSTD; MTBT1; MTBT2; PPND; tau; TAU; PHF-tau; paired helical filament-tau; neurofibrillary tangle protein; microtubule-associated protein tau, isoform 4; G protein beta1/gamma2 subunit-interacting factor 1; DDPAC; MAPTL; FTDP-17; |
Gene ID : | 4137 |
mRNA Refseq : | NM_001123066 |
Protein Refseq : | NP_001116538 |
MIM : | 157140 |
UniProt ID : | P10636 |
Products Types
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Mapt-2928R | Recombinant Rat Mapt protein(2-752aa), His-tagged | +Inquiry |
Mapt-3222M | Recombinant Mouse Mapt protein(2-733aa), His-tagged | +Inquiry |
MAPT-01C | Recombinant Cynomolgus MAPT Protein, His tagged | +Inquiry |
◆ Lysates | ||
MAPT-4478HCL | Recombinant Human MAPT 293 Cell Lysate | +Inquiry |
MAPT-4476HCL | Recombinant Human MAPT 293 Cell Lysate | +Inquiry |
MAPT-4477HCL | Recombinant Human MAPT 293 Cell Lysate | +Inquiry |
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Customer Reviews (3)
Write a reviewWestern-blot experiments using MAPT as a target have shown highly reproducible results.
This stability of MAPT is very good and can maintain its original properties even after multiple uses.
MAPT's purity and consistency make it a top choice for Western-blot experiments.
Q&As (6)
Ask a questionThe degree of abnormal aggregation of MAMAP proteins can be assessed by a variety of methods, such as immunohistochemistry, immunofluorescence staining, Western blot, etc. These methods can detect and quantify abnormally aggregated MAPT proteins.
The MAPT protein is closely related to the nerve cytoskeleton. It is involved in regulating axon formation and maintenance, cytosolic flow, and the normal function of neurons by binding and stabilizing microtubules.
MAPT protein interacts with other proteins in the nervous system, such as α-synuclein, β-kinigin, etc. These interactions may be involved in regulating the structure and function of neurons.
Yes, the expression of MAPT protein is affected by a variety of regulatory mechanisms, including transcriptional regulation, splicing regulation, phosphorylation regulation, etc. These regulatory mechanisms are essential for maintaining normal MAPT protein levels and function.
Future research directions include further elucidating the mechanism of abnormal aggregation and phosphorylation of MAPT protein, exploring the pathogenesis of genetic diseases associated with MAPT gene, finding therapeutic strategies to intervene in abnormal aggregation of MATT, and developing biomarkers related to MAPT protein for early diagnosis and therapeutic monitoring.
The MAPT protein plays an important role in clinical diagnosis. By measuring the level of the MAPT protein in the blood or cerebrospinal fluid, it can help identify different types of neurodegenerative diseases, such as Alzheimer's disease and prefrontal temporal dementia.
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