Recombinant Human MERTK Protein, Fc\Avi-tagged

Cat.No. : MERTK-175H
Product Overview : Biotinylated Recombinant Human MerTK (C-hFc-Avi) is produced by Human Cells. The target gene encoding Arg26-Ala499 is expressed with a C-hFc-Avi tag.
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Description : Tyrosine-protein kinase Mer(MERTK) is a member of the TYRO3/AXL/MER (TAM) receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
Source : Human Cells
Species : Human
Tag : Fc&Avi
Form : Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
AA Sequence : Arg26-Ala499
Endotoxin : Less than 0.1 ng/ug (1 EU/ug).
Shipping : Ambient
Protein length : Arg26-Ala499
Gene Name : MERTK MER proto-oncogene, tyrosine kinase [ Homo sapiens (human) ]
Official Symbol : MERTK
Synonyms : MER; RP38; c-Eyk; c-mer; Tyro12
Gene ID : 10461
mRNA Refseq : NM_006343.3
Protein Refseq : NP_006334.2
MIM : 604705
UniProt ID : Q12866

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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04/08/2022

    Fast shipping and excellent service. This product is a lab essential.

    06/15/2020

      Highly recommend for quality and prompt delivery.

      03/25/2018

        Exceptional product, outstanding customer service!

        Q&As (5)

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        In cancer biology, how does MERTK contribute to tumor progression and metastasis, and are there potential therapeutic strategies targeting MERTK in cancer treatment? 02/18/2022

        MERTK's involvement in cancer includes promoting tumor cell survival and metastasis. Targeting MERTK is under investigation as a potential therapeutic strategy in cancer treatment.

        How does the Gas6-MERTK signaling axis contribute to cellular processes beyond phagocytosis, and what downstream effectors are activated upon MERTK activation? 07/27/2021

        The Gas6-MERTK signaling axis influences diverse cellular processes, activating downstream effectors such as PI3K/Akt and MAPK pathways. Understanding these signaling events provides insights into MERTK's functional diversity.

        In neurobiology, what is the role of MERTK in microglial phagocytosis and synaptic pruning, and how does this impact neural circuitry development? 03/10/2020

        MERTK is involved in microglial phagocytosis and synaptic pruning, contributing to neural circuitry development. Dysregulation may affect synaptic connectivity, with implications for neurodevelopmental disorders.

        What is the role of MERTK in the regulation of immune responses, and how does its dysregulation contribute to autoimmune disorders and inflammatory diseases? 09/03/2019

        MERTK is involved in immune regulation, influencing inflammatory responses. Dysregulation of MERTK has been implicated in autoimmune disorders, emphasizing its role in maintaining immune homeostasis.

        What experimental techniques are commonly used to study MERTK, including its ligands, downstream signaling pathways, and cellular functions? 12/04/2018

        Techniques such as co-immunoprecipitation, flow cytometry, and advanced imaging methods are commonly used to study MERTK, providing insights into ligand interactions, signaling pathways, and cellular functions.

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