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Recombinant Human MLKL Protein (1-471 aa), His-SUMO-tagged

Cat.No. : MLKL-1098H
Product Overview : Recombinant Human MLKL Protein (1-471 aa) is produced by E. coli expression system. This protein is fused with a 6xHis-SUMO tag at the N-terminal. Research Area: Signal Transduction. Protein Description: Full Length.
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Description : Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma mbrane and execution of programmed necrosis characterized by calcium influx and plasma mbrane damage. Does not have protein kinase activity.
Source : E. coli
Species : Human
Tag : His-SUMO
Form : Tris-based buffer, 50% glycerol
Molecular Mass : 70.5 kDa
Protein length : 1-471 aa
AA Sequence : MENLKHIITLGQVIHKRCEEMKYCK KQCRRLGHRVLGLIKPLEMLQDQGK RSVPSEKLTTAMNRFKAALEEANGE IEKFSNRSNICRFLTASQDKILFKD VNRKLSDVWKELSLLLQVEQRMPVS PISQGASWAQEDQQDADEDRRAFQM LRRDNEKIEASLRRLEINMKEIKET LRQYLPPKCMQEIPQEQIKEIKKEQ LSGSPWILLRENEVSTLYKGEYHRA PVAIKVFKKLQAGSIAIVRQTFNKE IKTMKKFESPNILRIFGICIDETVT PPQFSIVMEYCELGTLRELLDREKD LTLGKRMVLVLGAARGLYRLHHSEA PELHGKIRSSNFLVTQGYQVKLAGF ELRKTQTSMSLGTTREKTDRVKSTA YLSPQELEDVFYQYDVKSEIYSFGI VLWEIATGDIPFQGCNSEKIRKLVA VKRQQEPLGEDCPSELREIIDECRA HDPSVRPSVDEILKKLSTFSK
Purity : > 90% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Concentration : A hardcopy of COA with concentration instruction is sent along with the products.
Gene Name : MLKL mixed lineage kinase domain-like [ Homo sapiens ]
Official Symbol : MLKL
Synonyms : MLKL; FLJ34389;
Gene ID : 197259
mRNA Refseq : NM_001142497
Protein Refseq : NP_001135969
UniProt ID : Q8NB16

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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