Recombinant Human MOG Protein (Gly30-Tyr149), His tagged
Cat.No. : | MOG-4585H |
Product Overview : | Recombinant human MOG (Gly30-Tyr149) fused with His tag was expressed in E. coli. |
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Description : | Myelin oligodendrocyte glycoprotein (MOG) is a transmembrane protein belonging to immunoglobulin superfamily, and contains an Ig-like domain followed by two potential membrane-spanning regions. MOG is expressed only in the CNS with very low content (approximately.1% total proteins) in oligodendrogliocyte membrane. Three possible functions for MOG were suggested: (a) a cellular adhesive molecule, (b) a regulator of oligodendrocyte microtubule stability, and (c) a mediator of interactions between myelin and the immune system, in particular, the complement cascade. A direct interaction might exist between the membrane-associated regions of MOG and the myelin-specific glycolipid galactocerebroside (Gal-C), and such an interaction may have important consequences regarding the membrane topology and function of both molecules. It is considered that MOG is an autoantigen capable to produce a demyelinating multiple sclerosis-like disease in experimental animals. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Lyophilized powder/frozen liquid |
Molecular Mass : | 15.39 kDa |
Protein Length : | Gly30-Tyr149 |
Purity : | >90% as determined by SDS-PAGE. |
Notes : | For research use only. |
Storage : | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt. |
Storage Buffer : | Supplied as solution form in PBS, pH 7.5 or lyophilized from PBS, pH 7.5. |
Reconstitution : | Reconstitute in sterile water for a stock solution. |
Shipping : | They are shipped out with dry ice/blue ice unless customers require otherwise. |
Gene Name : | MOG myelin oligodendrocyte glycoprotein [ Homo sapiens (human) ] |
Official Symbol : | MOG |
Synonyms : | MOG; myelin oligodendrocyte glycoprotein; myelin-oligodendrocyte glycoprotein; MOG Ig-AluB; MOG alpha-5; MOGIG2; NRCLP7; MGC26137; |
Gene ID : | 4340 |
mRNA Refseq : | NM_001008228 |
Protein Refseq : | NP_001008229 |
MIM : | 159465 |
UniProt ID : | Q16653 |
Products Types
◆ Recombinant Protein | ||
MOG-02H | Recombinant Human MOG Protein, His/Avi-tagged, Biotinylated | +Inquiry |
Mog-6988M | Recombinant Mouse Mog protein(Gly29-Thr156), His-tagged | +Inquiry |
MOG-063H | Recombinant Human MOG Protein, C-6×His-tagged | +Inquiry |
MOG-5466H | Recombinant Human MOG Protein, GST-tagged | +Inquiry |
Mog-4111M | Recombinant Mouse Mog Protein, Myc/DDK-tagged | +Inquiry |
◆ Native Protein | ||
MOG-20 | Native Mouse/Rat MOG (35-55) Protein | +Inquiry |
◆ Lysates | ||
MOG-1126HCL | Recombinant Human MOG cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewExcellent in protein studies.
Reliable, efficient, and effective.
Worked well, great quality.
Q&As (7)
Ask a questionMOG is predominantly expressed on the outer surface of the myelin sheath in the central nervous system.
MOG is a target in autoimmune demyelinating diseases, where the immune system mistakenly attacks it, damaging the myelin sheath.
MOG antibody testing helps diagnose and distinguish different demyelinating diseases, and therapies aim to modulate the immune response to prevent MOG attack.
There are no widely recognized genetic mutations in MOG associated with neurological conditions, but research is ongoing.
MOG contributes to myelin integrity, aiding in proper nerve signal transmission.
MOG antibodies are found in a subset of MS patients, but their exact role in MS pathogenesis is still under investigation.
MOG is involved in the maintenance and stability of the myelin sheath in the central nervous system.
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