| Description : |
This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
80.6 kDa |
| AA Sequence : |
MSTADALDDENTFKILVATDIHLGF MEKDAVRGNDTFVTLDEILRLAQEN EVDFILLGGDLFHENKPSRKTLHTC LELLRKYCMGDRPVQFEILSDQSVN FGFSKFPWVNYQDGNLNISIPVFSI HGNHDDPTGADALCALDILSCAGFV NHFGRSMSVEKIDISPVLLQKGSTK IALYGLGSIPDERLYRMFVNKKVTM LRPKEDENSWFNLFVIHQNRSKHGS TNFIPEQFLDDFIDLVIWGHEHECK IAPTKNEQQLFYISQPGSSVVTSLS PGEAVKKHVGLLRIKGRKMNMHKIP LHTVRQFFMEDIVLANHPDIFNPDN PKVTQAIQSFCLEKIEEMLENAERE RLGNSHQPEKPLVRLRVDYSGGFEP FSVLRFSQKFVDRVANPKDIIHFFR HREQKEKTGEEINFGKLITKPSEGT TLRVEDLVKQYFQTAEKNVQLSLLT ERGMGEAVQEFVDKEEKDAIEELVK YQLEKTQRFLKERHIDALEDKIDEE VRRFRETRQKNTNEEDDEVREAMTR ARALRSQSEESASAFSADDLMSIDL AEQMANDSDDSISAATNKGRGRGRG RRGGRGQNSASRGGSQRGRADTGLE TSTRSRNSKTAVSASRNMSIIDAFK STRQQPSRNVTTKNYSEVIEVDESD VEEDIFPTTSKTDQRWSSTSSSKIM SQSQVSKGVDFESSEDDDDDPFMNT SSLRRNRRTRTRPLEQKLISEEDLA ANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
