Recombinant Human MTPN Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: MTPN-2319H
• Product Overview: MTPN MS Standard C13 and N15-labeled recombinant protein (NP_665807) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: The transcript produced from this gene is bi-cistronic and can encode both myotrophin and leucine zipper protein 6. The myotrophin protein is associated with cardiac hypertrophy, where it is involved in the conversion of NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers. This protein also has a potential function in cerebellar morphogenesis, and it may be involved in the differentiation of cerebellar neurons, particularly of granule cells. A cryptic ORF at the 3' end of this transcript uses a novel internal ribosome entry site and a non-AUG translation initiation codon to produce leucine zipper protein 6, a 6.4 kDa tumor antigen that is associated with myeloproliferative disease.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 12.9 kDa
• AA Sequence: MCDKEFMWALKNGDLDEVKDYVAKG EDVNRTLEGGRKPLHYAADCGQLEI LEFLLLKGADINAPDKHHITPLLSA VYEGHVSCVKLLLSKGADKTVKGPD GLTAFEATDNQAIKALLQSGPTRTR PLEQKLISEEDLAANDILDYKDDDD KV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: MTPN myotrophin [ Homo sapiens (human) ]
• Official Symbol: MTPN
• Synonyms: MTPN; myotrophin; GCDP; granule cell differentiation protein; MYOTROPHIN; V 1
• Gene ID: 136319
• mRNA Refseq: NM_145808
• Protein Refseq: NP_665807
• MIM: 606484
• UniProt ID: P58546