Recombinant Human MVB12B Protein, MYC/DDK-tagged

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Recombinant Human MVB12B Protein, MYC/DDK-tagged

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Cat.No. : MVB12B-2337H
Product Overview : Recombinant human MVB12B protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293
Description : The protein encoded by this gene is a component of the ESCRT-I complex, a heterotetramer, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle. ESCRT-I complex plays an essential role in HIV budding and endosomal protein sorting. Depletion and overexpression of this and related protein (MVB12A) inhibit HIV-1 infectivity and induce unusual viral assembly defects, indicating a role for MVB12 subunits in regulating ESCRT-mediated virus budding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011].
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 24.3 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : MVB12B multivesicular body subunit 12B [ Homo sapiens ]
Official Symbol : MVB12B
Synonyms : C9orf28; FAM125B
Gene ID : 89853
mRNA Refseq : NM_001011703.2
Protein Refseq : NP_001011703

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