Recombinant Human Nanog

• Cat.No.: NANOG-3604H
• Product Overview: Recombinant human NANOG protein was expressed in E.coli and purified by using conventional chromatography (1-305aa).

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Protein Length: 1-305 a.a.
• Description: Nanog homeobox, also known as nanog, is a member of the homeobox family of DNA binding transcription factors that has been shown to maintain pluripotency of embryonic stem cells. Nanog expression counteracts the differentiation-promoting signals induced by the extrinsic factors LIF, Stat3 and BMP. Once NANOG expression is downregulated, cell differentiation can proceed. Proteins which regulate NANOG expression include transcription factors Oct4, SOX2, FoxD3, and Tcf3 and tumor suppressor p53.
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M Urea, 5% glycerol
• Molecular Weight: 34.6 kDa (305aa)
• Purity: > 90% by SDS - PAGE
• Concentration: 1 mg/ml (determined by Bradford assay)
• Sequences of amino acids: MSVDPACPQS LPCFEASDCK ESSPMPVICG PEENYPSLQM SSAEMPHTET VSPLPSSMDL LIQDSPDSST SPKGKQPTSA EKSVAKKEDK VPVKKQKTRT VFSSTQLCVL NDRFQRQKYL SLQQMQELSN ILNLSYKQVK TWFQNQRMKS KRWQKNNWPK NSNGVTQKAS APTYPSLYSS YHQGCLVNPT GNLPMWSNQT WNNSTWSNQT QNIQSWSNHS WNTQTWCTQS WNNQAWNSPF YNCGEESLQS CMQFQPNSPA SDLEAALEAA GEGLNVIQQT TRYFSTPQTM DLFLNYSMNM QPEDV
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: NANOG Nanog homeobox [ Homo sapiens ]
• Official Symbol: NANOG
• Synonyms: Nanog homeobox; NANOG; homeobox transcription factor Nanog; homeobox transcription factor Nanog-delta 48; FLJ12581; FLJ40451; hNanog; Homeobox transcription factor Nanog; Nanog homeobox
• Gene ID: 79923
• mRNA Refseq: NM_024865
• Protein Refseq: NP_079141
• MIM: 607937
• UniProt ID: Q9H9S0
• Chromosome Location: 12p13.31
• Function: sequence-specific DNA binding; transcription factor activity