Recombinant Human NCR3 protein, His-Avi-tagged

• Cat.No.: NCR3-582H
• Product Overview: Human NKp30 Protein is expressed from mammalian with His Tag and Avi Tag at the C-terminal. It contains Leu19-Thr138.

Specification

• Description: NKp30, along with NKp44 and NKp46, constitute a group of receptors termed "Natural Cytotoxicity Receptors". These receptors play a major role in triggering NK-mediated killing of most tumor cells lines.NKp30 stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation.
• Source: HEK293
• Species: Human
• Tag: His-Avi
• Form: Supplied as 0.22um filtered solution in PBS (pH 7.4).
• Molecular Mass: The protein has a predicted MW of 20 KDa. Due to glycosylation, the protein migrates to 26- 45KDa based on Bis-Tris PAGE result.
• Protein length: Leu19-Thr138
• Endotoxin: Less than 0.05EU per ug by the LAL method.
• Purity: > 95% as determined by SDS-PAGE; > 95% as determined by HPLC
• Storage: The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.

Gene Information

• Gene Name: NCR3
• Official Symbol: NCR3
• Synonyms: CD337 antigen; CD337; Activating natural killer receptor p30; CD337activating NK-A1 receptor; LY117,1C7NK-p30; lymphocyte antigen 117; natural cytotoxicity triggering receptor 3; Natural killer cell p30-related protein; NCR3; NKp30; NKp30MALS
• Gene ID: 259197
• mRNA Refseq: NM_001145466.1
• Protein Refseq: NP_001138938.1
• MIM: 611550
• UniProt ID: O14931