Recombinant Human NKX3-1, His-tagged

• Cat.No.: NKX3-1-7100H
• Product Overview: Recombinant human NKX3-1 protein, fused to His-tag at N-terminus, was expressed in E.coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-234aa
• Description: NKX3-1 is a homeobox-containing transcription factor, which binds preferentially the consensus sequence 5"-TAAGT[AG]-3" and can behave as a transcriptional repressor. This transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue. Aberrant expression of NKX3-1 is associated with prostate tumor progression. Alternate splicing results in multiple transcript variants of this.
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 2M UREA, 10% glycerol
• Molecular Mass: 28.7kDa (257aa)
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSMLRVPEP RPGEAKAEGA APPTPSKPLT SFLIQDILRD GAQRQGGRTS SQRQRDPEPE PEPEPEGGRSRAGAQNDQLS TGPRAAPEEA ETLAETEPER HLGSYLLDSE NTSGALPRLP QTPKQPQKRS RAAFSHTQVI ELERKFSHQK YLSAPERAHL AKNLKLTETQ VKIWFQNRRY KTKRKQLSSE LGDLEKHSSL PALKEEAFSR ASLVSVYNSY PYYPYLYCVG SWSPAFW
• Purity: >85% by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Concentration: 0.5 mg/ml

Gene Information

• Gene Name: NKX3-1 NK3 homeobox 1 [ Homo sapiens ]
• Official Symbol: NKX3-1
• Synonyms: NKX3-1; NK3 homeobox 1; NK homeobox (Drosophila), family 3, A , NK3 transcription factor related, locus 1 (Drosophila) , NKX3A; homeobox protein Nkx-3.1; BAPX2; NKX3.1; NK homeobox, family 3, A; homeobox protein NK-3 homolog A; NK3 transcription factor homolog A; NK3 transcription factor related, locus 1; NKX3; NKX3A
• Gene ID: 4824
• mRNA Refseq: NM_001256339
• Protein Refseq: NP_001243268
• MIM: 602041
• UniProt ID: Q99801
• Chromosome Location: 8p21.2
• Pathway: Coregulation of Androgen receptor activity, organism-specific biosystem; FOXA1 transcription factor network, organism-specific biosystem; Pathways in cancer, organism-specific biosystem; Prostate cancer, organism-specific biosystem; Prostate cancer, conserved biosystem; SIDS Susceptibility Pathways, organism-specific biosystem
• Function: androgen receptor activity; core promoter binding; contributes_to cysteine-type endopeptidase activator activity involved in apoptotic process; estrogen receptor activity; estrogen receptor binding; histone deacetylase binding; protein binding; protein binding transcription factor activity; protein kinase activator activity; protein self-association; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding transcription factor activity; transcription factor binding; transcription regulatory region DNA binding; transcription regulatory region sequence-specific DNA binding