Active Recombinant Human NOG Protein

• Cat.No.: NOG-001H
• Product Overview: Recombinant Human Noggin consisting of two 205 amino acid polypeptide chains without tag was expressed in HEK293 cells.

Specification

• Source: HEK293
• Species: Human
• Bio-activity: Determined by its ability to inhibit 5.0 ng/ml of BMP-4 induced alkaline phosphatase production by ATDC chondrogenic cells. The expected ED50 for this effect is 2.0-3.0 ng/ml of Noggin.
• Molecular Mass: 46 kDa
• AA Sequence: QHYLHIRPAPSDNLPLVDLIEHPDP IFDPKEKDLNETLLRSLLGGHYDPG FMATSPPEDRPGGGGGAAGGAEDLA ELDQLLRQRPSGAMPSEIKGLEFSE GLAQGKKQRLSKKLRRKLQMWLWSQ TFCPVLYAWNDLGSRFWPRYVKVGS CFSKRSCSVPEGMVCKPSKSVHLTV LRWRCQRRGGQRCGWIPIQYPIISE CKCSC
• Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.

Gene Information

• Gene Name: NOG noggin [ Homo sapiens (human) ]
• Official Symbol: NOG
• Synonyms: NOG; noggin; SYM1; SYNS1; SYNS1A
• Gene ID: 9241
• mRNA Refseq: NM_005450
• Protein Refseq: NP_005441
• MIM: 602991
• UniProt ID: Q13253

Reviews

07/15/2022

Efficient peptide synthesis, accelerates our peptide research projects.

04/30/2018

Fast and reliable protein expression, aids our experiments significantly.

01/25/2018

Dependable antibody validation, crucial for our immunoprecipitation studies.

Q&As

How does NOG (Noggin) modulate bone morphogenetic protein (BMP) signaling in development and tissue repair?

NOG inhibits BMP signaling, critical for tissue development and repair processes.

What are the mechanisms by which NOG modulates embryonic patterning and organogenesis?

NOG modulates embryonic patterning and organogenesis, guiding proper organ development.

How do alterations in NOG expression or function affect the development of congenital anomalies?

Changes in NOG expression or function can lead to congenital anomalies due to disrupted developmental processes.

How does NOG contribute to the regulation of stem cell differentiation?

NOG regulates stem cell differentiation, influencing their development into various tissue types.

What role does NOG play in skeletal development and the regulation of bone growth?

NOG plays a key role in skeletal development by regulating bone growth and differentiation.

How does NOG influence neural development and neurogenesis?

NOG influences neural development, impacting the formation and specialization of neural cells.

What is the impact of NOG in joint and cartilage health, particularly in arthritis?

NOG is important for joint and cartilage health, potentially impacting arthritis progression.