Recombinant Human NPC1 protein, His/FLAG-tagged
Cat.No. : | NPC1-1339H |
Product Overview : | Recombinant Human NPC1(Arg372-Phe622) fused with His/FLAG tag at N-terminal was expressed in HEK293. |
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- Gene Information
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Source : | HEK293 |
Species : | Human |
Tag : | His/FLAG |
Predicted N Terminal : | His |
Form : | Lyophilized from sterile PBS, pH 7.4.1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.2. Please contact us for any concerns or special requirements. |
Molecular Mass : | The recombinant human NPC1 consists 278 amino acids and predicts a molecular mass of 32 kDa. |
Protein length : | Arg372-Phe622 |
Endotoxin : | < 1.0 EU per μg protein as determined by the LAL method. |
Purity : | > 95 % as determined by SDS-PAGE |
Stability : | Samples are stable for up to twelve months from date of receipt at -70 centigrade |
Storage : | Store it under sterile conditions at -20 centigrade to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information. |
Shipping : | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. |
Publication : |
Multifunctional Pan-ebolavirus Antibody Recognizes a Site of Broad Vulnerability on the Ebolavirus Glycoprotein (2018)
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Gene Name : | NPC1 Niemann-Pick disease, type C1 [ Homo sapiens ] |
Official Symbol : | NPC1 |
Synonyms : | NPC1; Niemann-Pick disease, type C1; Niemann-Pick C1 protein; NPC; FLJ98532; |
Gene ID : | 4864 |
mRNA Refseq : | NM_000271 |
Protein Refseq : | NP_000262 |
MIM : | 607623 |
UniProt ID : | O15118 |
Chromosome Location : | 18q11-q12 |
Pathway : | Lysosome, organism-specific biosystem; Lysosome, conserved biosystem; |
Function : | hedgehog receptor activity; protein binding; receptor activity; sterol transporter activity; transmembrane signaling receptor activity; |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionMutations in the NPC1 protein can lead to degenerative changes in the nervous system, enlargement of organs, intellectual disability, and other characteristics.
Studies have shown that NPC1 protein mutations may affect neuroinflammatory responses, but the specific mechanism needs to be further studied.
The NPC1 protein plays an important role in intracellular cholesterol transport and metabolism, helping cells regulate cholesterol levels.
NPC1 protein is mainly localized in the endoplasmic reticulum and Golgi apparatus, and is involved in cholesterol transport and metabolic regulation.
The full name of NPC1 protein is Niemann-Pick C1 protein.
Mutations in the NPC1 protein are associated with Niemann-Pick disease type C, a rare inherited metabolic disorder that affects nervous system and liver function.
Customer Reviews (3)
Write a reviewThe background is very clean and there is no immunogenicity.
The NPC1 is very productive and can meet a large number of my needs.
It is very stable and can be stored and used for a long time.
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