Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human NPC1 protein, His/FLAG-tagged

Cat.No. : NPC1-1339H
Product Overview : Recombinant Human NPC1(Arg372-Phe622) fused with His/FLAG tag at N-terminal was expressed in HEK293.
Unit
Price
Qty
  • Specification
  • Gene Information
  • Related Products
Source : HEK293
Species : Human
Tag : His/FLAG
Predicted N Terminal : His
Form : Lyophilized from sterile PBS, pH 7.4.1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.2. Please contact us for any concerns or special requirements.
Molecular Mass : The recombinant human NPC1 consists 278 amino acids and predicts a molecular mass of 32 kDa.
Protein length : Arg372-Phe622
Endotoxin : < 1.0 EU per μg protein as determined by the LAL method.
Purity : > 95 % as determined by SDS-PAGE
Stability : Samples are stable for up to twelve months from date of receipt at -70 centigrade
Storage : Store it under sterile conditions at -20 centigrade to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Shipping : In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Publication :
Multifunctional Pan-ebolavirus Antibody Recognizes a Site of Broad Vulnerability on the Ebolavirus Glycoprotein (2018)
Gene Name : NPC1 Niemann-Pick disease, type C1 [ Homo sapiens ]
Official Symbol : NPC1
Synonyms : NPC1; Niemann-Pick disease, type C1; Niemann-Pick C1 protein; NPC; FLJ98532;
Gene ID : 4864
mRNA Refseq : NM_000271
Protein Refseq : NP_000262
MIM : 607623
UniProt ID : O15118
Chromosome Location : 18q11-q12
Pathway : Lysosome, organism-specific biosystem; Lysosome, conserved biosystem;
Function : hedgehog receptor activity; protein binding; receptor activity; sterol transporter activity; transmembrane signaling receptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (6)

Ask a question
What are the characteristics of the phenotype caused by mutations in the NPC1 protein? 10/05/2022

Mutations in the NPC1 protein can lead to degenerative changes in the nervous system, enlargement of organs, intellectual disability, and other characteristics.

Does NPC1 protein mutation affect the neuroinflammatory response? 06/21/2021

Studies have shown that NPC1 protein mutations may affect neuroinflammatory responses, but the specific mechanism needs to be further studied.

Does NPC1 have a role in cholesterol metabolism? 12/29/2020

The NPC1 protein plays an important role in intracellular cholesterol transport and metabolism, helping cells regulate cholesterol levels.

Does NPC1 protein localize in cells? 11/20/2020

NPC1 protein is mainly localized in the endoplasmic reticulum and Golgi apparatus, and is involved in cholesterol transport and metabolic regulation.

What is the full name of NPC1 protein? 09/13/2020

The full name of NPC1 protein is Niemann-Pick C1 protein.

What diseases are NPC1 protein mutations associated with? 04/20/2020

Mutations in the NPC1 protein are associated with Niemann-Pick disease type C, a rare inherited metabolic disorder that affects nervous system and liver function.

Customer Reviews (3)

Write a review
Reviews
12/09/2020

    The background is very clean and there is no immunogenicity.

    05/18/2020

      The NPC1 is very productive and can meet a large number of my needs.

      02/15/2020

        It is very stable and can be stored and used for a long time.

        Ask a Question for All NPC1 Products

        Required fields are marked with *

        My Review for All NPC1 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends