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Recombinant Human OSM protein, His-Avi-tagged, Biotinylated

Cat.No. : OSM-725HB
Product Overview : Biotinylated Recombinant Human Oncostatin M Protein is expressed from mammalian with His Tag and Avi Tag at the C-terminal. It contains Ala26-Arg221.
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Description : OSM is a pleiotropic cytokine that initiates its biological activities by binding to specific cell surface receptors. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDSKS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIFR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration.
Source : HEK293
Species : Human
Tag : His-Avi
Form : Supplied as 0.22μm filtered solution in 20mM PBS,pH7.4
Molecular Mass : The protein has a predicted MW of 25.1 KDa. Due to glycosylation, the protein migrates to 30-40KDa based on Bis-Tris PAGE result.
Protein length : Ala26-Arg221
Endotoxin : Less than 0.05EU per μg by the LAL method.
Purity : >95% as determined by Tris-Bis PAGE; >95% as determined by HPLC
Storage : The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.
Gene Name : OSM
Official Symbol : OSM
Synonyms : MGC20461; oncostatin M; oncostatin-M; OSM
Gene ID : 5008
mRNA Refseq : NM_001319108.2
Protein Refseq : NP_001306037.1
MIM : 165095
UniProt ID : P13725

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What is the impact of OSM on cancer development and progression, particularly in terms of tumor microenvironment modulation? 03/25/2022

OSM can influence cancer progression by altering the tumor microenvironment and affecting tumor cell behavior.

How does OSM (Oncostatin M) regulate inflammatory and immune responses in the body? 01/30/2021

OSM plays a key role in regulating inflammatory and immune responses, modulating cytokine production and immune cell activity.

How does OSM contribute to wound healing and tissue regeneration processes? 06/08/2020

OSM aids in wound healing and tissue regeneration, promoting cell growth and repair mechanisms.

What role does OSM play in the pathogenesis of autoimmune diseases like rheumatoid arthritis? 04/27/2020

OSM is implicated in autoimmune diseases, contributing to inflammation and joint damage in conditions like rheumatoid arthritis.

How does OSM influence liver fibrosis and hepatic diseases? 03/17/2020

OSM is involved in liver fibrosis, impacting the development and progression of hepatic diseases.

What are the mechanisms by which OSM modulates cellular growth, differentiation, and apoptosis? 06/22/2018

OSM regulates cellular processes like growth, differentiation, and apoptosis, affecting various tissue functions.

How do alterations in OSM expression or signaling affect cardiovascular health and disease? 02/20/2018

Changes in OSM signaling can impact cardiovascular health, influencing disease development and progression.

Customer Reviews (3)

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Reviews
11/25/2020

    Outstanding protein-protein interaction studies, vital for our projects.

    03/02/2020

      High-quality protein characterization, fundamental for our experiments.

      02/27/2019

        Expertise in peptide synthesis, accelerates our peptide-based research.

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