Description : |
The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene. |
Source : |
HEK293 |
Species : |
Human |
Tag : |
Myc/DDK |
Molecular Mass : |
104.6 kDa |
AA Sequence : |
MAASRLDFGEVETFLDRHPELFEDY LMRKGKQEMVEKWLQRHSQGQGALG PRPSLAGTSSLAHSTCRGGSSVGGG TGPNGSAHSQPLPGGGDCGGVPLSP SWAGGSRGDGNLQRRASQKELRKSF ARSKAIHVNRTYDEQVTSRAQEPLS SVRRRALLRKASSLPPTTAHILSAL LESRVNLPQYPPTAIDYKCHLKKHN ERQFFLELVKDISNDLDLTSLSYKI LIFVCLMVDADRCSLFLVEGAAAGK KTLVSKFFDVHAGTPLLPCSSTENS NEVQVPWGKGIIGYVGEHGETVNIP DAYQDRRFNDEIDKLTGYKTKSLLC MPIRSSDGEIIGVAQAINKIPEGAP FTEDDEKVMQMYLPFCGIAISNAQL FAASRKEYERSRALLEVVNDLFEEQ TDLEKIVKKIMHRAQTLLKCERCSV LLLEDIESPVVKFTKSFELMSPKCS ADAENSFKESMEKSSYSDWLINNSI AELVASTGLPVNISDAYQDPRFDAE ADQISGFHIRSVLCVPIWNSNHQII GVAQVLNRLDGKPFDDADQRLFEAF VIFCGLGINNTIMYDQVKKSWAKQS VALDVLSYHATCSKAEVDKFKAANI PLVSELAIDDIHFDDFSLDVDAMIT AALRMFMELGMVQKFKIDYETLCRW LLTVRKNYRMVLYHNWRHAFNVCQL MFAMLTTAGFQDILTEVEILAVIVG CLCHDLDHRGTNNAFQAKSGSALAQ LYGTSATLEHHHFNHAVMILQSEGH NIFANLSSKEYSDLMQLLKQSILAT DLTLYFERRTEFFELVSKGEYDWNI KNHRDIFRSMLMTACDLGAVTKPWE ISRQVAELVTSEFFEQGDRERLELK LTPSAIFDRNRKDELPRLQLEWIDS ICMPLYQALVKVNVKLKPMLDSVAT NRSKWEELHQKRLLASTASSSPASV MVAKEDRNTRTRPLEQKLISEEDLA ANDILDYKDDDDKV |
Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : |
50 μg/mL as determined by BCA |
Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |