Recombinant Human PLAU Protein, MYC/DDK-tagged

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Recombinant Human PLAU Protein, MYC/DDK-tagged

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Cat.No. : PLAU-1868H
Product Overview : Recombinant human PLAU protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293
Description : This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016].
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 46.3 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : PLAU plasminogen activator, urokinase [ Homo sapiens ]
Official Symbol : PLAU
Synonyms : ATF; BDPLT5; QPD; u-PA; UPA; URK
Gene ID : 5328
mRNA Refseq : NM_001145031
Protein Refseq : NP_001138503
MIM : 191840
UniProt ID : P00749

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