Recombinant Human PNPLA3 Protein, MYC/DDK-tagged, C13 and N15-labeled

• Cat.No.: PNPLA3-091H
• Product Overview: PNPLA3 MS Standard C13 and N15-labeled recombinant protein (NP_079501) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: The protein encoded by this gene is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. The encoded protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 52.8 kDa
• AA Sequence: MYDAERGWSLSFAGCGFLGFYHVGA TRCLSEHAPHLLRDARMLFGASAGA LHCVGVLSGIPLEQTLQVLSDLVRK ARSRNIGIFHPSFNLSKFLRQGLGK CLPANVHQLISGKIGISLTRVSDGE NVLVSDFRSKDEVVDALVCSCFMPF YSGLIPPSFRGVRYVDGGVSDNVPF IDAKTTITVSPFYGEYDICPKVKST NFLHVDITKLSLRLCTGNLYLLSRA FVPPDLKVLGEICLRGYLDAFRFLE EKGICNRPQPGLKSSSEGMDPEVAM PSWANMSLDSSPESAALAVRLEGDE LLDHLRLSILPWDESILDTLSPRLA TALSEEMKDKGGYMSKICNLLPIRI MSYVMLPCTLPVESAIAIVQRLVTW LPDMPDDVLWLQWVTSQVFTRVLMC LLPASRSQMPVSSQQASPCTPEQDW PCWTPCSPEGCPAETKAEATPRSIL RSSLNFFLGNKVPAGAEGLSTFPSF SLEKSLTRTRPLEQKLISEEDLAAN DILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: PNPLA3 patatin like phospholipase domain containing 3 [ Homo sapiens (human) ]
• Official Symbol: PNPLA3
• Synonyms: PNPLA3; patatin like phospholipase domain containing 3; ADPN; C22orf20; iPLA(2)epsilon; 1-acylglycerol-3-phosphate O-acyltransferase PNPLA3; acylglycerol O-acyltransferase; acylglycerol transacylase; adiponutrin; calcium-independent phospholipase A2-epsilon; iPLA2-epsilon; iPLA2epsilon; lysophosphatidic acid acyltransferase; patatin-like phospholipase domain-containing protein 3; EC 2.3.1.51; EC 3.1.1.3
• Gene ID: 80339
• mRNA Refseq: NM_025225
• Protein Refseq: NP_079501
• MIM: 609567
• UniProt ID: Q9NST1

Reviews

03/21/2022

Manufacturers should ensure the consistency and quality of PNPLA3 protein products.

04/09/2017

The PNPLA3 protein offered by the manufacturer exhibits exceptional quality and is precisely tailored to meet my experimental requirements.

11/02/2016

Its purity, stability, and functionality make it an ideal choice for my research endeavors.

Q&As

Does PNPLA3 play a role in other health conditions beyond liver disease?

PNPLA3 primarily influences lipid metabolism and liver health, but there may be connections with other metabolic disorders.

Can changes in diet and lifestyle help individuals with PNPLA3-related liver conditions?

Yes, dietary and lifestyle modifications, such as weight loss and reduced alcohol consumption, can help manage liver diseases associated with PNPLA3 variants.

How does PNPLA3 affect liver fibrosis progression in NAFLD patients?

PNPLA3 variants may accelerate liver fibrosis in NAFLD, making it a potential marker for disease severity.

Can children inherit PNPLA3 variants from their parents?

Yes, PNPLA3 gene variants can be inherited from parents and can increase the risk of liver diseases in children.

Are there any medications or therapies targeting PNPLA3 for the treatment of liver diseases?

There are no specific drugs targeting PNPLA3, but therapies for liver diseases often take into account a patient's genetic profile, including PNPLA3 variants.