Recombinant Human PRF1 protein, His-tagged
Cat.No. : | PRF1-158H |
Product Overview : | Recombinant Human PRF1 protein(Pro22~Trp555), fused to N-terminal His tag, was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | 20mM Tris, 150mM NaCl, pH8.0, containing 0.05% sarcosyl and 5% trehalose |
Molecular Mass : | 63kDa as determined by SDS-PAGE reducing conditions. |
Protein length : | Pro22~Trp555 |
Endotoxin : | < 1.0 EU per μg protein as determined by the LAL method. |
Purity : | > 80 % |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. |
Reconstitution : | Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0mg/mL. Do not vortex. |
Gene Name : | PRF1 perforin 1 (pore forming protein) [ Homo sapiens ] |
Official Symbol : | PRF1 |
Synonyms : | PRF1; perforin 1 (pore forming protein); perforin-1; HPLH2; P1; Perforin; perforin 1 (preforming protein); PFP; cytolysin; lymphocyte pore forming protein; lymphocyte pore-forming protein; FLH2; PFN1; MGC65093; |
Gene ID : | 5551 |
mRNA Refseq : | NM_001083116 |
Protein Refseq : | NP_001076585 |
MIM : | 170280 |
UniProt ID : | P14222 |
Products Types
◆ Recombinant Protein | ||
PRF1-3904H | Recombinant Human PRF1 Protein, His (Fc)-Avi-tagged | +Inquiry |
PRF1-738R | Recombinant Rat PRF1 Protein (25-554 aa), His-tagged | +Inquiry |
PRF1-1931M | Recombinant Mouse PRF1 Protein (21-554 aa), His-tagged | +Inquiry |
PRF1-1942H | Recombinant Human PRF1, His-tagged | +Inquiry |
PRF1-01H | Recombinant Human PRF1 Protein, His-Tagged | +Inquiry |
◆ Native Protein | ||
PRF1-55H | Native Human Perforin | +Inquiry |
◆ Lysates | ||
PRF1-2873HCL | Recombinant Human PRF1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
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Q&As (7)
Ask a questionSignaling pathways and stimuli such as T cell receptor (TCR) activation and exposure to infected cells influence the expression of perforin (PRF1) in immune cells.
PRF1 expression is particularly upregulated or modulated in cytotoxic immune cells such as cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells.
Dysregulation or abnormal expression of PRF1 is associated with conditions like hemophagocytic lymphohistiocytosis (HLH) and certain autoimmune disorders.
Perforin (PRF1) expression changes during immune activation, often being upregulated in response to various stimuli.
The balance between upregulation and downregulation of PRF1 is influenced by various factors, including the type of immune response and the microenvironment.
Altered PRF1 expression is significant for immune surveillance, as it plays a crucial role in the cytotoxicity of immune cells against infected or aberrant cells.
PRF1 contributes to immune responses by enabling immune cells to induce apoptosis in target cells, contributing to cytotoxicity.
Customer Reviews (3)
Write a reviewWe observed remarkable consistency in product performance across multiple batches, reducing variability in our experiments.
The manufacturer's history of producing high-quality products contributed to our trust in this protein.
Collaboration with other research groups was made easier by the product's standardized use in the scientific community.
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