Recombinant Human Proinsulin protein
Cat.No. : | INS-315H |
Product Overview : | Recombinant Human Proinsulin(Phe25 -Asn110) was expressed in E. coli. |
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Description : | After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. |
Source : | E. coli |
Species : | Human |
Molecular Mass : | 9394.67 Da |
AA Sequence : | FVNQHLCGSHLVEALYLVCGERGFF YTPKTRREAEDLQVGQVELGGGPGA GSLQPLALEGSLQKRGIVEQCCTS ICSLYQLENYCN |
Purity : | >99% |
Storage : | Lyophilized peptide is shipped at ambient temperature.12 months from date of receipt, -20°C to -70 °C as supplied.3 months, -20°C to -70 °C under sterile conditions after reconstitution.1 month, 2 to 8 °C under sterile conditions after reconstitution.Avoid multiple freeze-thaw cycles. |
Reconstitution : | Reconstitute to 1.0mg/mL in sterile phosphate buffered saline. |
Gene Name : | INS insulin [ Homo sapiens ] |
Official Symbol : | INS |
Synonyms : | INS; insulin; proinsulin; ILPR; IRDN; IDDM2; MODY10; |
Gene ID : | 3630 |
mRNA Refseq : | NM_000207 |
Protein Refseq : | NP_000198 |
MIM : | 176730 |
UniProt ID : | P01308 |
Chromosome Location : | 11p15.5 |
Pathway : | ATF-2 transcription factor network, organism-specific biosystem; Adipogenesis, organism-specific biosystem; Aldosterone-regulated sodium reabsorption, organism-specific biosystem; Aldosterone-regulated sodium reabsorption, conserved biosystem; Amyloids, organism-specific biosystem; Arf6 trafficking events, organism-specific biosystem; Developmental Biology, organism-specific biosystem; |
Function : | hormone activity; hormone activity; hormone activity; insulin receptor binding; insulin receptor binding; insulin-like growth factor receptor binding; protein binding; |
Products Types
◆ Recombinant Protein | ||
INS-2689C | Recombinant Chicken INS Protein, His-tagged | +Inquiry |
INS-856H | Recombinant Human INS Protein, His-tagged | +Inquiry |
INS-369C | Recombinant Cynomolgus Monkey INS Protein, His (Fc)-Avi-tagged | +Inquiry |
INS-5100H | Recombinant Human INS Protein, GST-tagged | +Inquiry |
INS-1187H | Recombinant Human INS Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Native Protein | ||
INS-5435B | Native Bovine Insulin | +Inquiry |
INS-512D | Native Bovine INS | +Inquiry |
◆ Lysates | ||
INS-5195HCL | Recombinant Human INS 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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