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Recombinant Human Protein Kinase C, Iota, GST-tagged, Active

Cat.No. : PRKCI-405H
Product Overview : Recombinant human full-length PKCiota was expressed by baculovirus inSf9 cellsusing an N-terminal GST tag. MW=98 kDa.
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Cat. No. : PRKCI-405H
Description : PKCι is a member of the protein kinase C family of serine-threonine kinases. The amino acid sequence of PKCι showed greatest homology to PKCzeta, with 72% identity overall rising to 84% in the catalytic domain. Protein kinase C iota (PKCι) has been implicated in Ras signaling and is a critical downstream effector of oncogenic Ras in the colonic epithelium. Transgenic mice expressing constitutively active PKCι in the colon are highly susceptible to carcinogen-induced colon carcinogenesis.
Source : Sf9 insect cells using baculovirus.
Sequence : Full-length.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : PRKCI protein kinase C, iota [ Homo sapiens ]
Synonyms : PRKCI; protein kinase C, iota; PKCI; DXS1179E; MGC26534; nPKC-iota; EC 2.7.11.13; Protein kinase C iota type; Atypical protein kinase C-lambda/iota; aPKC-lambda/iota; PRKC-lambda/iota
Gene ID : 5584
mRNA Refseq : NM_002740
Protein Refseq : NP_002731
UniProt ID : P41743
Chromosome Location : 3q26.3
MIM : 600539
Pathway : Tight junction; Signalling by NGF; Endocytosis; Insulin signaling pathway; Cell-cell adhesion systems
Function : ATP binding; protein kinase C activity; metal ion binding; nucleotide binding; transferase activity; zinc ion binding; phospholipid binding; protein binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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