Recombinant Human PSCA protein, His-tagged

• Cat.No.: PSCA-2003H
• Product Overview: Recombinant Human PSCA(Leu22~Ser95) fused with His tag at N-terminal was expressed in E. coli.

Specification

• Description: This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene includes a polymorphism that results in an upstream start codon in some individuals; this polymorphism is thought to be associated with a risk for certain gastric and bladder cancers. Alternative splicing results in multiple transcript variants.
• Source: E. coli
• Species: Human
• Tag: His
• Form: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300
• Molecular Mass: 9.6kDa
• Protein length: Leu22~Ser95
• Endotoxin: <1.0EU per 1µg (determined by the LAL method)
• Purity: > 95%
• Applications: SDS-PAGE; WB; ELISA; IP
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Reconstitution: Reconstitute in PBS or others.

Gene Information

• Gene Name: PSCA prostate stem cell antigen [ Homo sapiens ]
• Official Symbol: PSCA
• Synonyms: PSCA; prostate stem cell antigen; PRO232
• Gene ID: 8000
• mRNA Refseq: NM_005672
• Protein Refseq: NP_005663
• MIM: 602470
• UniProt ID: O43653
• Chromosome Location: 8q24.2

Reviews

12/04/2019

User-friendly data analysis capabilities contributed to the product's overall value for our research.

07/27/2017

The software and resources provided by the manufacturer greatly facilitated the extraction of meaningful insights from our data.

02/21/2017

The product's user-friendly features facilitated seamless collaboration among team members with different expertise levels.

Q&As

Does PSCA have any known genetic variations?

Genetic variations in PSCA have been studied, and certain polymorphisms may be associated with cancer susceptibility.

Are there therapeutic implications related to PSCA?

PSCA is being explored as a potential target for therapeutic interventions in prostate cancer treatment.

In which context is PSCA commonly studied?

PSCA is often studied in the context of prostate cancer, as it is overexpressed in prostate cancer cells.

What is the role of PSCA in prostate cancer?

PSCA may play a role in prostate cancer progression, and its overexpression is associated with malignancy.

What does PSCA stand for?

PSCA stands for Prostate Stem Cell Antigen.

Can PSCA be a potential biomarker for prostate cancer?

Yes, PSCA is considered a potential biomarker for prostate cancer due to its overexpression in prostate cancer cells.

Is PSCA expressed only in the prostate?

While PSCA is notably expressed in the prostate, its expression has also been reported in other tissues and organs.