Recombinant Human PTPRK Protein, Myc/DDK-tagged, C13 and N15-labeled

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Recombinant Human PTPRK Protein, Myc/DDK-tagged, C13 and N15-labeled

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Cat.No. : PTPRK-5497H
Product Overview : PTPRK MS Standard C13 and N15-labeled recombinant protein (NP_001129120) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
Description : The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 163.02 kDa
AA Sequence : MDTTAAAALP AFVALLLLSP WPLLGSAQGQ FSAGGCTFDD GPGACDYHQD LYDDFEWVHV SAQEPHYLPP EMPQGSYMIV DSSDHDPGEK ARLQLPTMKE NDTHCIDFSY LLYSQKGLNP GTLNILVRVN KGPLANPIWN VTGFTGRDWL RAELAVSTFW PNEYQVIFEA EVSGGRSGYI AIDDIQVLSY PCDKSPHFLR LGDVEVNAGQ NATFQCIATG RDAVHNKLWL QRRNGEDIPV AQTKNINHRR FAASFRLQEV TKTDQDLYRC VTQSERGSGV SNFAQLIVRE PPRPIAPPQL LGVGPTYLLI QLNANSIIGD GPIILKEVEY RMTSGSWTET HAVNAPTYKL WHLDPDTEYE IRVLLTRPGE GGTGLPGPPL ITRTKCAEPM RTPKTLKIAE IQARRIAVDW ESLGYNITRC HTFNVTICYH YFRGHNESKA DCLDMDPKAP QHVVNHLPPY TNVSLKMILT NPEGRKESEE TIIQTDEDVP GPVPVKSLQG TSFENKIFLN WKEPLDPNGI ITQYEISYSS IRSFDPAVPV AGPPQTVSNL WNSTHHVFMH LHPGTTYQFF IRASTVKGFG PATAINVTTN ISAPTLPDYE GVDASLNETA TTITVLLRPA QAKGAPISAY QIVVEELHPH RTKREAGAME CYQVPVTYQN AMSGGAPYYF AAELPPGNLP EPAPFTVGDN RTYQGFWNPP LAPRKGYNIY FQAMSSVEKE TKTQCVRIAT KAAATEEPEV IPDPAKQTDR VVKIAGISAG ILVFILLLLV VILIVKKSKL AKKRKDAMGN TRQEMTHMVN AMDRSYADQS TLHAEDPLSI TFMDQHNFSP RYENHSATAE SSRLLDVPRY LCEGTESPYQ TGQLHPAIRV ADLLQHINLM KTSDSYGFKE EYESFFEGQS ASWDVAKKDQ NRAKNRYGNI IAYDHSRVIL QPVEDDPSSD YINANYIDIW LYRDGYQRPS HYIATQGPVH ETVYDFWRMI WQEQSACIVM VTNLVEVGRV KCYKYWPDDT EVYGDFKVTC VEMEPLAEYV VRTFTLERRG YNEIREVKQF HFTGWPDHGV PYHATGLLSF IRRVKLSNPP SAGPIVVHCS AGAGRTGCYI VIDIMLDMAE REGVVDIYNC VKALRSRRIN MVQTEEQYIF IHDAILEACL CGETAIPVCE FKAAYFDMIR IDSQTNSSHL KDEFQTLNSV TPRLQAEDCS IACLPRNHDK NRFMDMLPPD RCLPFLITID GESSNYINAA LMDSYRQPAA FIVTQYPLPN TVKDFWRLVY DYGCTSIVML NEVDLSQGCP QYWPEEGMLR YGPIQVECMS CSMDCDVINR IFRICNLTRP QEGYLMVQQF QYLGWASHRE VPGSKRSFLK LILQVEKWQE ECEEGEGRTI IHCLNGGGRS GMFCAIGIVV EMVKRQNVVD VFHAVKTLRN SKPNMVEAPE QYRFCYDVAL EYLESSSGPT RTRRLEQKLI SEEDLAANDI LDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
SDS-PAGE :

Gene Name : PTPRK protein tyrosine phosphatase receptor type K [ Homo sapiens (human) ]
Official Symbol : PTPRK
Synonyms : PTPRK; protein tyrosine phosphatase, receptor type, K; receptor-type tyrosine-protein phosphatase kappa; R PTP kappa; protein-tyrosine phosphatase kappa; protein-tyrosine phosphatase, receptor type, kappa; dJ480J14.2.1 (protein tyrosine phosphatase, receptor type, K (R-PTP-KAPPA, protein tyrosine phosphatase kappa, protein tyrosine phosphatase kappa; R-PTP-kappa; DKFZp686C2268; DKFZp779N1045;
Gene ID : 5796
mRNA Refseq : NM_001135648
Protein Refseq : NP_001129120
MIM : 602545
UniProt ID : Q15262
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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