| Description : |
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
163.02 kDa |
| AA Sequence : |
MDTTAAAALPAFVALLLLSPWPLLG SAQGQFSAGGCTFDDGPGACDYHQD LYDDFEWVHVSAQEPHYLPPEMPQG SYMIVDSSDHDPGEKARLQLPTMKE NDTHCIDFSYLLYSQKGLNPGTLNI LVRVNKGPLANPIWNVTGFTGRDWL RAELAVSTFWPNEYQVIFEAEVSGG RSGYIAIDDIQVLSYPCDKSPHFLR LGDVEVNAGQNATFQCIATGRDAVH NKLWLQRRNGEDIPVAQTKNINHRR FAASFRLQEVTKTDQDLYRCVTQSE RGSGVSNFAQLIVREPPRPIAPPQL LGVGPTYLLIQLNANSIIGDGPIIL KEVEYRMTSGSWTETHAVNAPTYKL WHLDPDTEYEIRVLLTRPGEGGTGL PGPPLITRTKCAEPMRTPKTLKIAE IQARRIAVDWESLGYNITRCHTFNV TICYHYFRGHNESKADCLDMDPKAP QHVVNHLPPYTNVSLKMILTNPEGR KESEETIIQTDEDVPGPVPVKSLQG TSFENKIFLNWKEPLDPNGIITQYE ISYSSIRSFDPAVPVAGPPQTVSNL WNSTHHVFMHLHPGTTYQFFIRAST VKGFGPATAINVTTNISAPTLPDYE GVDASLNETATTITVLLRPAQAKGA PISAYQIVVEELHPHRTKREAGAME CYQVPVTYQNAMSGGAPYYFAAELP PGNLPEPAPFTVGDNRTYQGFWNPP LAPRKGYNIYFQAMSSVEKETKTQC VRIATKAAATEEPEVIPDPAKQTDR VVKIAGISAGILVFILLLLVVILIV KKSKLAKKRKDAMGNTRQEMTHMVN AMDRSYADQSTLHAEDPLSITFMDQ HNFSPRYENHSATAESSRLLDVPRY LCEGTESPYQTGQLHPAIRVADLLQ HINLMKTSDSYGFKEEYESFFEGQS ASWDVAKKDQNRAKNRYGNIIAYDH SRVILQPVEDDPSSDYINANYIDIW LYRDGYQRPSHYIATQGPVHETVYD FWRMIWQEQSACIVMVTNLVEVGRV KCYKYWPDDTEVYGDFKVTCVEMEP LAEYVVRTFTLERRGYNEIREVKQF HFTGWPDHGVPYHATGLLSFIRRVK LSNPPSAGPIVVHCSAGAGRTGCYI VIDIMLDMAEREGVVDIYNCVKALR SRRINMVQTEEQYIFIHDAILEACL CGETAIPVCEFKAAYFDMIRIDSQT NSSHLKDEFQTLNSVTPRLQAEDCS IACLPRNHDKNRFMDMLPPDRCLPF LITIDGESSNYINAALMDSYRQPAA FIVTQYPLPNTVKDFWRLVYDYGCT SIVMLNEVDLSQGCPQYWPEEGMLR YGPIQVECMSCSMDCDVINRIFRIC NLTRPQEGYLMVQQFQYLGWASHRE VPGSKRSFLKLILQVEKWQEECEEG EGRTIIHCLNGGGRSGMFCAIGIVV EMVKRQNVVDVFHAVKTLRNSKPNM VEAPEQYRFCYDVALEYLESSSGPT RTRRLEQKLISEEDLAANDILDYKD DDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
