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Active Recombinant Human ROCK2 Protein, His-tagged

Cat.No. : ROCK2-1879H
Product Overview : Recombinant human ROCK2 (5-554) was expressed using baculovirus in Sf9 insect cells with an N-terminal His tag.
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  • Gene Information
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Description : The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho.
Source : Insect cells
Species : Human
Tag : His
Bio-activity : 605 nmol/min/mg
Molecular Mass : ~66 kDa
Purity : >95%
Stability : One year at -70 centigrade from the date of shipment.
Storage : Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration : 0.1 μg/μL
Storage Buffer : Recombinant protein stored in 50 mM sodium phosphate, pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.25 mM DTT, 25% glycerol.
Shipping : Shipped on dry ice.
Gene Name : ROCK2 Rho associated coiled-coil containing protein kinase 2 [ Homo sapiens (human) ]
Official Symbol : ROCK2
Synonyms : ROCK2; Rho associated coiled-coil containing protein kinase 2; ROCK-II; p164 ROCK-2; rho-associated, coiled-coil-containing protein kinase II; EC 2.7.11.1; rho-associated protein kinase 2
Gene ID : 9475
mRNA Refseq : NM_004850
Protein Refseq : NP_004841
MIM : 604002
UniProt ID : O75116

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Discuss the role of ROCK2 in smooth muscle contraction and vascular tone. 03/24/2022

ROCK2 is a key regulator of smooth muscle contraction, influencing vascular tone by phosphorylating myosin light chain and promoting actin-myosin interaction.

Describe the molecular crosstalk between ROCK2 and other signaling pathways. 08/07/2021

ROCK2 interacts with various signaling pathways, including Wnt, PI3K/Akt, and MAPK pathways, forming a network that regulates cell survival, proliferation, and differentiation.

How does ROCK2 contribute to the regulation of cell cycle progression? 12/04/2020

ROCK2 can influence the cell cycle by regulating cyclin-dependent kinase activity and promoting the phosphorylation of proteins involved in cell cycle checkpoints.

What are the implications of ROCK2 in cell migration and invasion? 03/18/2019

ROCK2 is involved in the regulation of cell migration and invasion by controlling actin dynamics and focal adhesion turnover, influencing processes like metastasis in cancer.

Discuss the role of ROCK2 in the regulation of the actin cytoskeleton. 06/11/2018

ROCK2 phosphorylates various downstream targets, such as myosin light chain, leading to actin-myosin contraction and the reorganization of the actin cytoskeleton.

Customer Reviews (3)

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Reviews
08/19/2021

    Swift and hassle-free delivery ensured our experiments stayed on track.

    01/13/2020

      Efficient customer service provided valuable insights for our decision-making.

      07/06/2019

        Reliable and precise—this recombined protein never disappoints.

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