Recombinant Human RPS6KB1 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: RPS6KB1-3720H
• Product Overview: RPS6KB1 MS Standard C13 and N15-labeled recombinant protein (NP_003152) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 59 kDa
• AA Sequence: MRRRRRRDGFYPAPDFRDREAEDMA GVFDIDLDQPEDAGSEDELEEGGQL NESMDHGGVGPYELGMEHCEKFEIS ETSVNRGPEKIRPECFELLRVLGKG GYGKVFQVRKVTGANTGKIFAMKVL KKAMIVRNAKDTAHTKAERNILEEV KHPFIVDLIYAFQTGGKLYLILEYL SGGELFMQLEREGIFMEDTACFYLA EISMALGHLHQKGIIYRDLKPENIM LNHQGHVKLTDFGLCKESIHDGTVT HTFCGTIEYMAPEILMRSGHNRAVD WWSLGALMYDMLTGAPPFTGENRKK TIDKILKCKLNLPPYLTQEARDLLK KLLKRNAASRLGAGPGDAGEVQAHP FFRHINWEELLARKVEPPFKPLLQS EEDVSQFDSKFTRQTPVDSPDDSTL SESANQVFLGFTYVAPSVLESVKEK FSFEPKIRSPRRFIGSPRTPVSPVK FSPGDFWGRGASASTANPQTPVEYP METSGIEQMDVTMSGEASAPLPIRQ PNSGPYKKQAFPMISKRPEHLRMNL TRTRPLEQKLISEEDLAANDILDYK DDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: RPS6KB1 ribosomal protein S6 kinase B1 [ Homo sapiens (human) ]
• Official Symbol: RPS6KB1
• Synonyms: RPS6KB1; ribosomal protein S6 kinase, 70kDa, polypeptide 1; ribosomal protein S6 kinase, 70kD, polypeptide 1, STK14A; ribosomal protein S6 kinase beta-1; p70(S6K) alpha; PS6K; S6K1; P70S6K1; p70 S6KA; S6K-beta-1; p70 S6K-alpha; p70 S6 kinase, alpha 1; p70 S6 kinase, alpha 2; ribosomal protein S6 kinase I; serine/threonine kinase 14 alpha; serine/threonine-protein kinase 14A; 70 kDa ribosomal protein S6 kinase 1; S6K; STK14A; p70-S6K; p70-alpha; p70(S6K)-alpha
• Gene ID: 6198
• mRNA Refseq: NM_003161
• Protein Refseq: NP_003152
• MIM: 608938
• UniProt ID: P23443