Recombinant Human SPN Protein, His-tagged

• Cat.No.: SPN-3246H
• Product Overview: Recombinant Human SPN Protein is produced by E. coli expression system. This protein is fused with a His tag at the N-terminal.

Specification

• Description: SPN is a major sialoglycoprotein found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B lymphocytes. It may be part of a physiologic ligand-receptor complex involved in T-cell activation. During T-cell activation, this protein is actively removed from the T-cell-APC (antigen-presenting cell) contact site, suggesting a negative regulatory role in adaptive immune response. Recombinant human SPN protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol.
• Molecular Mass: 25.8 kDa
• Protein length: 20-253 aa
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSSTTAVQT PTSGEPLVST SEPLSSKMYT TSITSDPKAD STGDQTSALP PSTSINEGSP LWTSIGASTG SPLPEPTTYQ EVSIKMSSVP QETPHATSHP
  AVPITANSLG SHTVTGGTIT TNSPETSSRT SGAPVTTAAS SLETSRGTSG PPLTMATVSL ETSKGTSGPP VTMATDSLET STGTTGPPVT MTTGSLEPSS GASGPQVSSV KLSTMMSPTT STNASTVPFR NPDENSR
• Purity: > 85% by SDS - PAGE
• Notes: For research use only. This product is not intended or approved for human, diagnostics or veterinary use.
• Storage: Can be stored at +2 centigrade to +8 centigrade for 1 week. For long term storage, aliquot and store at -20 centigrade to -80 centigrade. Avoid repeated freezing and thawing cycles.
• Concentration: 1 mg/ml (determined by Absorbance at 280nm)

Gene Information

• Gene Name: SPN sialophorin [ Homo sapiens ]
• Official Symbol: SPN
• Synonyms: SPN; sialophorin; leukosialin; CD43; GPL115; LSN; GALGP; galactoglycoprotein; leukocyte sialoglycoprotein
• Gene ID: 6693
• mRNA Refseq: NM_001030288
• Protein Refseq: NP_001025459
• MIM: 182160
• UniProt ID: P16150

Reviews

06/23/2023

Accurate and timely results, crucial for research progress.

10/02/2018

Instrumental in our research achievements, highly trusted.

03/26/2018

Efficient and dependable, aids our research significantly.

Q&As

What is the primary role of SPN in immune cell function?

SPN, or Sialophorin, is important in modulating the function of immune cells, particularly lymphocytes.

What potential therapeutic applications arise from targeting SPN in immune disorders?

Targeting SPN could provide new treatment approaches for managing immune-related conditions, including autoimmune diseases.

How do genetic variations in SPN affect immune response?

Genetic changes in SPN can lead to variations in immune cell behavior and effectiveness.

What role does SPN play in cell adhesion and migration?

SPN plays a role in regulating immune cell adhesion and migration, crucial for immune surveillance and response.

How does SPN interact with other components of the immune system?

SPN interacts with other immune molecules, coordinating immune cell communication and function.

What is the impact of altered SPN activity on autoimmune diseases?

Altered SPN activity can impact the regulation of immune responses, potentially leading to autoimmune disorders.

How does SPN contribute to immune cell signaling?

It contributes to immune cell signaling, influencing cell activation and response to stimuli.