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Active Recombinant Human TGFBR3, His-tagged

Cat.No. : TGFBR3-699H
Product Overview : The recombinant human TGFBR3/BGCAN ECD protein is expressed as a 772 amino acid protein consisting of Gly21 - Gly781 region of TGFBR3 (UniProt accession #Q03167) and a C-terminal His tag.
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Source : Human cells
Species : Human
Tag : His
Form : Supplied at 0.5 mg/ml in sterile PBS pH7.4 (carrier & preservative free).
Bio-activity : Immobilized TGFBR3 protein binds human TGFβ2 in a functional ELISA. Blocks TGFβ2-mediated signaling activity.
Molecular Mass : Calculated molecular mass (kDa): 85.7; Estimated by SDS-PAGE under reducing condition (kDa): 95-100
AA Sequence : GPEPGALCELSPVSASHPVQALMES FTVLSGCASRGTTGLPQEVHVLNLR TAGQGPGQLQREVTLHLNPISSVH IHHKSVVFLLNSPHPLVWHLKTERL ATGVSRLFLVSEGSVVQFSSANFSL TAETEERNFPHGNEHLLNWARKEY GAVTSFTELKIARNIYIKVGEDQVF PPKCNIGKNFLSLNYLAEYLQPKAA EGCVMSSQPQNEEVHIIELITPNS NPYSAFQVDITIDIRPSQEDLEVVK NLILILKCKKSVNWVIKSFDVKGSL KIIAPNSIGFGKESERSMTMTKSI RDDIPSTQGNLVKWALDNGYSPITS YTMAPVANRFHLRLENNAEEMGDEE VHTIPPELRILLDPGALPALQNP PIRGGEGQNGGLPFPFPDISRRVWN EEGEDGLPRPKDPVIPSIQLFPGLR EPEEVQGSVDIALSVKCDNEKMIV AVEKDSFQASGYSGMDVTLLDPTCK AKMNGTHFVLESPLNGCGTRPRWSA LDGVVYYNSIVIQVPALGDSSGWP DGYEDLESGDNGFPGDMDEGDASLF TRPEIVVFNCSLQQVRNPSSFQEQP HGNITFNMELYNTDLFLVPSQGVF SVPENGHVYVEVSVTKAEQELGFAI QTCFISPYSNPDRMSHYTIIENICP KDESVKFYSPKRVHFPIPQADMD KKRFSFVFKPVFNTSLLFLQCELTL CTKMEKHPQKLPKCVPPDEACTSLD ASIIWAMMQNKKTFTKPLAVIHHE AESKEKGPSMKEPNPISPPIFHGST GHHHHHHHH
Endotoxin : <0.1 eu per 1 μg of purified recombinant protein determined by the lal>
Purity : >75% judged by SDS-PAGE under reducing condition
Storage : The product is shipped at 4°C. Upon receipt, centrifuge the product briefly before opening the vial. It is recommended to store small aliquots at the temperature below –20°C for long-term storage and the product is stable for 3 months. The undiluted protein can be stored at 4°C for no more than 2 weeks. Avoid repeated freeze-thaw cycles.
Gene Name : TGFBR3 transforming growth factor, beta receptor III [ Homo sapiens ]
Official Symbol : TGFBR3
Synonyms : TGFBR3; transforming growth factor, beta receptor III; transforming growth factor, beta receptor III (betaglycan, 300kDa); transforming growth factor beta receptor type 3; betaglycan; betaglycan proteoglycan; BGCAN; TGFR-3; TGF-beta receptor type 3; TGF-beta receptor type III;
Gene ID : 7049
mRNA Refseq : NM_001195683
Protein Refseq : NP_001182612
MIM : 600742
UniProt ID : Q03167
Chromosome Location : 1p33-p32
Pathway : TGF Beta Signaling Pathway, organism-specific biosystem; TGF-beta Receptor Signaling Pathway, organism-specific biosystem; TGF-beta receptor signaling, organism-specific biosystem;
Function : PDZ domain binding; SMAD binding; coreceptor activity; glycosaminoglycan binding; glycosaminoglycan binding; heparin binding; protein binding; contributes_to protein binding; receptor activity; transforming growth factor beta binding; transforming growth factor beta receptor activity, type III; transforming growth factor beta receptor binding; transforming growth factor beta-activated receptor activity; type II transforming growth factor beta receptor binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What are the implications of TGFBR3 mutations in the context of hereditary connective tissue disorders? 03/05/2022

TGFBR3 mutations are associated with hereditary connective tissue disorders, impacting extracellular matrix homeostasis and contributing to conditions like Loeys-Dietz syndrome.

How does TGFBR3 influence embryonic development, and what are the consequences of its dysregulation during development? 04/26/2021

TGFBR3 plays a role in embryonic development, and dysregulation may lead to developmental abnormalities due to disrupted TGF-beta signaling.

Can you explain the role of TGFBR3 in mediating interactions between cells and extracellular matrix components? 07/15/2019

TGFBR3 facilitates cell-ECM interactions by modulating TGF-beta signaling, influencing processes like cell adhesion and migration.

How does TGFBR3 contribute to the modulation of TGF-beta signaling pathways? 05/24/2018

TGFBR3 acts as a co-receptor, enhancing the binding of TGF-beta ligands to TGF-beta receptors, and modulates downstream signaling events.

What are the functional consequences of TGFBR3 mutations in the context of cardiovascular diseases? 02/11/2018

TGFBR3 mutations are implicated in cardiovascular diseases, affecting TGF-beta-mediated processes in vascular smooth muscle cells and cardiac tissues.

Customer Reviews (3)

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Reviews
05/10/2022

    Great product !

    02/18/2020

      Seamless delivery process—ordered, received, and ready for experiments.

      08/31/2018

        Timely delivery is key, and this product arrived on schedule.

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