Active Recombinant Human TGFBR3, His-tagged
Cat.No. : | TGFBR3-699H |
Product Overview : | The recombinant human TGFBR3/BGCAN ECD protein is expressed as a 772 amino acid protein consisting of Gly21 - Gly781 region of TGFBR3 (UniProt accession #Q03167) and a C-terminal His tag. |
- Specification
- Gene Information
- Related Products
Source : | Human cells |
Species : | Human |
Tag : | His |
Form : | Supplied at 0.5 mg/ml in sterile PBS pH7.4 (carrier & preservative free). |
Bio-activity : | Immobilized TGFBR3 protein binds human TGFβ2 in a functional ELISA. Blocks TGFβ2-mediated signaling activity. |
Molecular Mass : | Calculated molecular mass (kDa): 85.7; Estimated by SDS-PAGE under reducing condition (kDa): 95-100 |
AA Sequence : | GPEPGALCELSPVSASHPVQALMES FTVLSGCASRGTTGLPQEVHVLNLR TAGQGPGQLQREVTLHLNPISSVH IHHKSVVFLLNSPHPLVWHLKTERL ATGVSRLFLVSEGSVVQFSSANFSL TAETEERNFPHGNEHLLNWARKEY GAVTSFTELKIARNIYIKVGEDQVF PPKCNIGKNFLSLNYLAEYLQPKAA EGCVMSSQPQNEEVHIIELITPNS NPYSAFQVDITIDIRPSQEDLEVVK NLILILKCKKSVNWVIKSFDVKGSL KIIAPNSIGFGKESERSMTMTKSI RDDIPSTQGNLVKWALDNGYSPITS YTMAPVANRFHLRLENNAEEMGDEE VHTIPPELRILLDPGALPALQNP PIRGGEGQNGGLPFPFPDISRRVWN EEGEDGLPRPKDPVIPSIQLFPGLR EPEEVQGSVDIALSVKCDNEKMIV AVEKDSFQASGYSGMDVTLLDPTCK AKMNGTHFVLESPLNGCGTRPRWSA LDGVVYYNSIVIQVPALGDSSGWP DGYEDLESGDNGFPGDMDEGDASLF TRPEIVVFNCSLQQVRNPSSFQEQP HGNITFNMELYNTDLFLVPSQGVF SVPENGHVYVEVSVTKAEQELGFAI QTCFISPYSNPDRMSHYTIIENICP KDESVKFYSPKRVHFPIPQADMD KKRFSFVFKPVFNTSLLFLQCELTL CTKMEKHPQKLPKCVPPDEACTSLD ASIIWAMMQNKKTFTKPLAVIHHE AESKEKGPSMKEPNPISPPIFHGST GHHHHHHHH |
Endotoxin : | <0.1 eu per 1 μg of purified recombinant protein determined by the lal>0.1> |
Purity : | >75% judged by SDS-PAGE under reducing condition |
Storage : | The product is shipped at 4°C. Upon receipt, centrifuge the product briefly before opening the vial. It is recommended to store small aliquots at the temperature below –20°C for long-term storage and the product is stable for 3 months. The undiluted protein can be stored at 4°C for no more than 2 weeks. Avoid repeated freeze-thaw cycles. |
Gene Name : | TGFBR3 transforming growth factor, beta receptor III [ Homo sapiens ] |
Official Symbol : | TGFBR3 |
Synonyms : | TGFBR3; transforming growth factor, beta receptor III; transforming growth factor, beta receptor III (betaglycan, 300kDa); transforming growth factor beta receptor type 3; betaglycan; betaglycan proteoglycan; BGCAN; TGFR-3; TGF-beta receptor type 3; TGF-beta receptor type III; |
Gene ID : | 7049 |
mRNA Refseq : | NM_001195683 |
Protein Refseq : | NP_001182612 |
MIM : | 600742 |
UniProt ID : | Q03167 |
Chromosome Location : | 1p33-p32 |
Pathway : | TGF Beta Signaling Pathway, organism-specific biosystem; TGF-beta Receptor Signaling Pathway, organism-specific biosystem; TGF-beta receptor signaling, organism-specific biosystem; |
Function : | PDZ domain binding; SMAD binding; coreceptor activity; glycosaminoglycan binding; glycosaminoglycan binding; heparin binding; protein binding; contributes_to protein binding; receptor activity; transforming growth factor beta binding; transforming growth factor beta receptor activity, type III; transforming growth factor beta receptor binding; transforming growth factor beta-activated receptor activity; type II transforming growth factor beta receptor binding; |
Products Types
◆ Recombinant Protein | ||
Tgfbr3-298R | Recombinant Rat Tgfbr3 Protein, His-tagged | +Inquiry |
Tgfbr3-297M | Recombinant Mouse Tgfbr3 Protein, His/GST-tagged | +Inquiry |
TGFBR3-4488H | Recombinant Human TGFBR3 Protein, His (Fc)-Avi-tagged | +Inquiry |
TGFBR3-5697R | Recombinant Rat TGFBR3 Protein, His (Fc)-Avi-tagged | +Inquiry |
Tgfbr3-9163M | Recombinant Mouse Tgfbr3 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
TGFBR3-001HCL | Recombinant Human TGFBR3 cell lysate | +Inquiry |
TGFBR3-1847MCL | Recombinant Mouse TGFBR3 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionTGFBR3 mutations are associated with hereditary connective tissue disorders, impacting extracellular matrix homeostasis and contributing to conditions like Loeys-Dietz syndrome.
TGFBR3 plays a role in embryonic development, and dysregulation may lead to developmental abnormalities due to disrupted TGF-beta signaling.
TGFBR3 facilitates cell-ECM interactions by modulating TGF-beta signaling, influencing processes like cell adhesion and migration.
TGFBR3 acts as a co-receptor, enhancing the binding of TGF-beta ligands to TGF-beta receptors, and modulates downstream signaling events.
TGFBR3 mutations are implicated in cardiovascular diseases, affecting TGF-beta-mediated processes in vascular smooth muscle cells and cardiac tissues.
Customer Reviews (3)
Write a reviewGreat product !
Seamless delivery process—ordered, received, and ready for experiments.
Timely delivery is key, and this product arrived on schedule.
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