Recombinant Human TP53 Protein, Myc/DDK-tagged, C13 and N15-labeled

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Recombinant Human TP53 Protein, Myc/DDK-tagged, C13 and N15-labeled

TP53 Related Products

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Cat.No. : TP53-489H
Product Overview : TP53 MS Standard C13 and N15-labeled recombinant protein (NP_000537) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
Description : This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277).
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 43.7 kDa
AA Sequence : Tag(s)MEEP QSDPSVEPPL SQETFSDLWK LLPENNVLSP LPSQAMDDLM LSPDDIEQWF TEDPGPDEAP RMPEAAPPVA PAPAAPTPAA PAPAPSWPLS SSVPSQKTYQ GSYGFRLGFL HSGTAKSVTC TYSPALNKMF CQLAKTCPVQ LWVDSTPPPG TRVRAMAIYK QSQHMTEVVR RCPHHERCSD SDGLAPPQHL IRVEGNLRVE YLDDRNTFRH SVVVPYEPPE VGSDCTTIHY NYMCNSSCMG GMNRRPILTI ITLEDSSGNL LGRNSFEVRV CACPGRDRRT EEENLRKKGE PHHELPPGST KRALPNNTSS SPQPKKKPLD GEYFTLQIRG RERFEMFREL NEALELKDAQ AGKEPGGSRA HSSHLKSKKG QSTSRHKKLM FKTEGPDSDT RTRPLEQKLI SEEDLAANDI LDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
SDS-PAGE :

Gene Name : TP53 tumor protein p53 [ Homo sapiens (human) ]
Official Symbol : TP53
Synonyms : TP53; tumor protein p53; cellular tumor antigen p53; LFS1; Li Fraumeni syndrome; p53; antigen NY-CO-13; mutant p53 protein; phosphoprotein p53; p53 tumor suppressor; truncated p53 protein; tumor suppressor TP53; transformation-related protein 53; P53; TRP53; FLJ92943;
Gene ID : 7157
mRNA Refseq : NM_000546
Protein Refseq : NP_000537
MIM : 191170
UniProt ID : P04637

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