Description : |
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity with many substrates including coumarins, phenols, anthraquinones, flavones, and some opioids. |
Source : |
HEK293 |
Species : |
Human |
Tag : |
Myc/DDK |
Molecular Mass : |
57.1 kDa |
AA Sequence : |
MARTGWTSPIPLCVSLLLTCGFAEA GKLLVVPMDGSHWFTMQSVVEKLIL RGHEVVVVMPEVSWQLGKSLNCTVK TYSTSYTLEDLDREFMDFADAQWKA QVRSLFSLFLSSSNGFFNLFFSHCR SLFNDRKLVEYLKESSFDAVFLDPF DACGLIVAKYFSLPSVVFARGIACH YLEEGAQCPAPLSYVPRILLGFSDA MTFKERVRNHIMHLEEHLFCQYFSK NALEIASEILQTPVTAYDLYSHTSI WLLRTDFVLDYPKPVMPNMIFIGGI NCHQGKPLPMEFEAYINASGEHGIV VFSLGSMVSEIPEKKAMAIADALGK IPQTVLWRYTGTRPSNLANNTILVK WLPQNDLLGHPMTRAFITHAGSHGV YESICNGVPMVMMPLFGDQMDNAKR METKGAGVTLNVLEMTSEDLENALK AVINDKSYKENIMRLSSLHKDRPVE PLDLAVFWVEFVMRHKGAPHLRPAA HDLTWYQYHSLDVIGFLLAVVLTVA FITFKCCAYGYRKCLGKKGRVKKAH KSKTHTRTRPLEQKLISEEDLAAND ILDYKDDDDKV |
Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : |
50 μg/mL as determined by BCA |
Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |