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Recombinant Mouse Alox5 Protein, MYC/DDK-tagged

Cat.No. : Alox5-583M
Product Overview : Purified recombinant protein of full-length mouse arachidonate 5-lipoxygenase (Alox5), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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  • Gene Information
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Description : Broad expression in lung adult (RPKM 3.4), heart adult (RPKM 2.7) and 22 other tissues.
Source : HEK293T
Species : Mouse
Tag : MYC/DDK
Molecular Mass : 78 kDa
Purity : >80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Alox5 arachidonate 5-lipoxygenase [ Mus musculus (house mouse) ]
Official Symbol : Alox5
Synonyms : Alox5; arachidonate 5-lipoxygenase; 5LO; 5LX; 5-LO; 5-LOX; AI850497; F730011J02; polyunsaturated fatty acid 5-lipoxygenase; 5-lipoxygenase; EC 1.13.11.34
Gene ID : 11689
mRNA Refseq : NM_009662
Protein Refseq : NP_033792
UniProt ID : P48999

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (13)

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On which chromosome is the ALOX5 coding gene? 02/15/2023

The ALOX5 coding gene is located on human chromosome 10.

What are ALOX5 inhibitors? What is their mechanism of action? 12/30/2022

Currently known ALOX5 inhibitors include trypanosomamine, Ritopane, MK-886, etc., whose mechanism of action is to interfere with the expression or function of ALOX5 in different ways, thereby playing an anti-inflammatory or anti-tumor role.

What biological processes is ALOX5 involved in? 12/27/2022

ALOX5 is involved in a variety of biological processes, including apoptosis, cell proliferation, inflammatory response, and cancer metastasis.

What factors can regulate ALOX5 gene expression? 10/20/2022

The gene expression can be regulated by a variety of factors such as prostaglandins, cytokines and interferons.

Which foods inhibit ALOX5 activity? 04/08/2022

Some foods rich in polyphenols, such as cucumbers, tomatoes, grapes, green tea, etc., are thought to inhibit ALOX5 activity.

What cell types have high levels of ALOX5 gene expression? 04/07/2022

In general, the ALOX5 gene is highly expressed in eosinophils and monocytes.

What is the function of the ALOX5 promoter region? 01/08/2022

The ALOX5 promoter region is the starting point of gene transcription and is responsible for mediating the transcription regulation of the ALOX5 gene.

How to inhibit the effect of ALOX5 in tumor treatment with drugs? 12/18/2021

Drugs that block the ALOX5 signaling pathway, such as Zileuton, MK886, and A861, have been shown to inhibit tumor cell proliferation and invasion. Currently, there are also many researchers who are exploring ALOX5 in tumors.

What diseases can ALOX5 gene mutation cause? 01/17/2021

ALOX5 gene mutation may cause asthma, allergic rhinitis, eczema and other allergic diseases.

What is 5-HETE? How is it related to ALOX5? 12/02/2020

5-HETE is one of the representative products of ALOX5 catalyzed synthesis, and is an activator of platelets and neutrophils.

What is the specific mechanism by which ALOX5 mediates the occurrence of human cancer? 11/07/2019

There is no definite answer to this question. Current studies believe that ALOX5 can affect the occurrence, development and metastasis of tumors through multiple ways, including regulating the proliferation, apoptosis, invasion and metastasis of tumor cells.

In what areas can ALOX5 knockout mouse models be used for research? 09/03/2019

ALOX5 knockout mouse models can be used to study a variety of biological processes and diseases, such as immune regulation, inflammation, asthma, eczema, autoimmunity, etc.

How to detect the expression of ALOX5 gene? 07/27/2019

At present, the commonly used methods include real-time fluorescent quantitative PCR, Northern blot, Western blot, etc.

Customer Reviews (3)

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Reviews
05/09/2022

    After ALOX5 application, the background of the Western blot was very clean with no nonspecific signal.

    08/10/2020

      ALOX5 significantly improved the experimental accuracy and made the experimental results more reliable.

      05/07/2020

        I appreciate the stability of ALOX5, which can be kept at room temperature for several days without spoilage.

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