Recombinant Mouse Amh Protein, MYC/DDK-tagged
Cat.No. : | Amh-592M |
Product Overview : | Purified recombinant protein of full-length mouse anti-Mullerian hormone (Amh), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
- Specification
- Gene Information
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Description : | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active noncovalent complex. This complex binds to the anti-Mullerian hormone receptor type 2 and causes the regression of Mullerian ducts in the male embryo that would otherwise differentiate into the uterus and fallopian tubes. This protein also plays a role in Leydig cell differentiation and function and follicular development in adult females. Homozygous knockout male mice develop female reproductive organs and are often sterile, while homozygous knockout female mice exhibit premature depletion of primordial follicles. |
Source : | HEK293T |
Species : | Mouse |
Tag : | MYC/DDK |
Molecular Mass : | 59.8 kDa |
Purity : | >80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Amh anti-Mullerian hormone [ Mus musculus (house mouse) ] |
Official Symbol : | Amh |
Synonyms : | Amh; anti-Mullerian hormone; MIS; muellerian-inhibiting factor; Mullerian inhibiting substance; anti-Muellerian hormone; muellerian-inhibiting substance |
Gene ID : | 11705 |
mRNA Refseq : | NM_007445 |
Protein Refseq : | NP_031471 |
UniProt ID : | Q5EC55 |
Products Types
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionAMH interacts with hormones like FSH and estrogen to modulate the balance between follicular development and follicle selection.
AMH expression is influenced by genetic variations and epigenetic modifications that can contribute to inter-individual differences in AMH levels.
AMH inhibits the development of M眉llerian ducts in males, promoting the differentiation of Sertoli cells and the formation of the male reproductive system.
Deficiency or overexpression of AMH can lead to reproductive abnormalities, such as altered fertility, impaired gonadal development, or disorders of sexual differentiation.
In females, AMH plays a role in regulating the regression of M眉llerian ducts and inhibiting follicular development.
Modulating AMH signaling pathways may hold therapeutic potential for infertility treatments and the management of reproductive disorders by manipulating follicular development or regulating reproductive organ development.
Dysregulation of AMH has been associated with reproductive disorders, including polycystic ovary syndrome (PCOS) characterized by increased AMH levels, and disorders of sexual development (DSD) associated with AMH deficiency or insensitivity.
AMH levels can serve as a valuable biomarker for assessing ovarian reserve and predicting ovarian response to fertility treatments like in vitro fertilization (IVF).
AMH expression is tightly regulated during gonadal development and sex determination, primarily controlled by the transcription factors involved in testis development, such as SRY (Sex-determining Region Y) protein.
AMH activates the transforming growth factor-beta (TGF-尾) signaling pathway, which plays a crucial role in regulating reproductive organ development and functions.
Customer Reviews (3)
Write a reviewReduced assay optimization time for faster results.
High-throughput compatibility for efficient data acquisition.
Stable reagents for long-term assay reproducibility.
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