Recombinant Mouse Ang Protein, MYC/DDK-tagged

• Cat.No.: Ang-602M
• Product Overview: Purified recombinant protein of full-length mouse angiogenin, ribonuclease, RNase A family, 5 (Ang), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: This gene encodes a member of the pancreatic ribonuclease A superfamily and is a potent inducer of neovascularization. The encoded protein is a secreted multifunctional tRNA-specific ribonuclease that promotes angiogenesis in response to angiogenetic stimuli such as hypoxia, mediates stress-induced translational repression by cleaving cellular tRNAs, stimulates cell proliferation by mediating rRNA transcription in prostate cancer cells, and is involved in neurite pathfinding. This gene resides in a cluster of highly related genes. It shares dual promoters and 5' exons with the ribonuclease, RNase A family 4 gene. Two alternatively spliced variants, with different 5' exons but the same coding exon, have been identified. Multiple pseudogenes have been found for this gene.
• Source: HEK293T
• Species: Mouse
• Tag: MYC/DDK
• Molecular Mass: 16.2 kDa
• Purity: >80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Ang angiogenin, ribonuclease, RNase A family, 5 [ Mus musculus (house mouse) ]
• Official Symbol: Ang
• Synonyms: Ang; angiogenin, ribonuclease, RNase A family, 5; Ang1; Rnase5; Rnase5a; AI385586; angiogenin; RNase 5; angiogenin, ribonuclease A family, member 1; angiogenin-1; ribonuclease 5; EC 3.1.27.-
• Gene ID: 11727
• mRNA Refseq: NM_007447
• Protein Refseq: NP_031473
• UniProt ID: P21570